SIS3

Tocris Bioscience, part of Bio-Techne | Catalog # 5291

Selective Smad3 inhibitor; inhibits TGF-βR1 signaling
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Key Product Details

Description

Selective Smad3 inhibitor; inhibits TGF-βR1 signaling

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Product Description

SIS3 is a selective Smad3 inhibitor; attenuates TGF-β1-dependent Smad3 phosphorylation and DNA binding. Has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. Inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts. Also inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.

Product Specifications

Molecular Weight

489.99

Formula

C28H27N3O3.HCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline hydrochloride

CAS Number

521984-48-5

PubChem ID

16079005

InChI Key

CDKIEBFIMCSCBB-CALJPSDSSA-N

SMILES

O=C(N4CCC(C=C(OC)C(OC)=C5)=C5C4)/C=C/C2=C(C3=CC=CC=C3)N(C)C1=NC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49 100

Preparing Stock Solutions for SIS3

The following data is based on the product molecular weight 489.99

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.20 mL 20.41 mL
5 mM 0.41 mL 2.04 mL 4.08 mL
10 mM 0.20 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

Calculators

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Product Documents for SIS3

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SIS3

For research use only

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