Sipatrigine

Name: Sipatrigine
Brand: Tocris Bioscience
SKU: 4044

Tocris Bioscience, part of Bio-Techne | Catalog # 4044

Citations (2)

COA / SDS

NaV blocker; neuroprotective

Key Product Details

Description:	Na_V blocker; neuroprotective
Alternative Names:	619C89
Chemical Name:	2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	372.68

View Full Technical Details for Sipatrigine

Technical Data
Citations

Biological Activity for Sipatrigine

Sipatrigine is a blocker of voltage-dependent sodium channels (Na_V). Inhibits glutamate release; displays neuroprotective activity in rat models of cerebral ischemia. Also thought to block Ca²⁺ channels. Analog of lamotrigine (Cat. No. 1611).

Technical Data for Sipatrigine

M. Wt	372.68
Formula	C₁₅H₁₆Cl₃N₅
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	130800-90-7
PubChem ID	60803
InChi Key	PDOCBJADCWMDGL-UHFFFAOYSA-N
Smiles	ClC1=CC(Cl)=C(Cl)C(C2=C(N)N=C(N3CCN(C)CC3)N=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sipatrigine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.27	100
	ethanol	9.32	25

Preparing Stock Solutions for Sipatrigine

The following data is based on the product molecular weight 372.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.42 mL	26.83 mL
5 mM	0.54 mL	2.68 mL	5.37 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for Sipatrigine

References are publications that support the biological activity of the product.

Graham Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion. J.Pharmacol.Exp.Ther. 1994 PMID: 7910213
Stefani On the inhibition of voltage activated calcium currents in rat cortical neurones by the neuroprotective agent 619C89. Br.J.Pharmacol. 1998 PMID: 9846645
Leach BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 1993 PMID: 8100654