Lamotrigine

Name: Lamotrigine
Brand: Tocris Bioscience
SKU: 1611

Catalog # 1611 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

Inhibits glutamate release. Anticonvulsant

Key Product Details

Description:	Inhibits glutamate release. Anticonvulsant
Chemical Name:	6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
Purity:	≥99% (HPLC)
Molecular Weight:	256.09

View Full Technical Details for Lamotrigine

Technical Data
Citations (2) / Reviews

Biological Activity for Lamotrigine

Lamotrigine is an anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na⁺, K⁺ and Ca²⁺ currents. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na⁺ channels.

Water-soluble Salt also available.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for Lamotrigine

M. Wt	256.09
Formula	C₉H₇Cl₂N₅
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	84057-84-1
PubChem ID	3878
InChi Key	PYZRQGJRPPTADH-UHFFFAOYSA-N
Smiles	NC1=NC(N)=C(N=N1)C1=CC=CC(Cl)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lamotrigine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.61	100

Preparing Stock Solutions for Lamotrigine

The following data is based on the product molecular weight 256.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.90 mL	19.52 mL	39.05 mL
5 mM	0.78 mL	3.90 mL	7.81 mL
10 mM	0.39 mL	1.95 mL	3.90 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

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References for Lamotrigine

References are publications that support the biological activity of the product.

Zheng The anticonvulsive drug lamotr. blocks neuronal α4β2 nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 2010 PMID: 20688974
Grunze Modulation of calcium and potassium currents by lamotr. Neuropsychobiology 1998 PMID: 9778600
Zona and Avoli Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 1997 PMID: 9184596
Leach Neurochemical and behavioral aspects of lamotr. Epilepsia 1991 PMID: 1685439

Citations for Lamotrigine (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Lamotrigine include:

Kashyap et al. (2015) Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation. J Neurosci. 2
PMID: 26709376
Lazar et al. (2015) Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway. Front Pharmacol. 6:210
PMID: 26441665

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