Lamotrigine isethionate

Name: Lamotrigine isethionate
Brand: Tocris Bioscience
SKU: 2289

Catalog # 2289 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Inhibits glutamate release. Water-soluble salt of lamotrigine (Cat. No. 1611)

Key Product Details

Description:	Inhibits glutamate release. Water-soluble salt of lamotrigine (Cat. No. 1611)
Chemical Name:	6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine isethionate
Purity:	≥99% (HPLC)
Molecular Weight:	382.22

View Full Technical Details for Lamotrigine isethionate

Technical Data
Citations (1) / Reviews

Biological Activity for Lamotrigine isethionate

Lamotrigine isethionate is a water-soluble salt of lamotrigine (Cat. No. 1611). Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na⁺, K⁺ and Ca²⁺ currents.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for Lamotrigine isethionate

M. Wt	382.22
Formula	C₉H₇Cl₂N₅.C₂H₆O₄S
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	113170-86-8
PubChem ID	45039646
InChi Key	CJIDZLNMKONKAD-UHFFFAOYSA-N
Smiles	OCCS(O)(=O)=O.NC1=NC(N)=C(N=N1)C1=CC=CC(Cl)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Lamotrigine isethionate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	38.22	100 with gentle warming

Preparing Stock Solutions for Lamotrigine isethionate

The following data is based on the product molecular weight 382.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.62 mL	13.08 mL	26.16 mL
5 mM	0.52 mL	2.62 mL	5.23 mL
10 mM	0.26 mL	1.31 mL	2.62 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for Lamotrigine isethionate

References are publications that support the biological activity of the product.

Grunze Modulation of calcium and potassium currents by lamotr. Neuropsychobiology 1998 PMID: 9778600
Zona and Avoli Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 1997 PMID: 9184596
Smith and Meldrum Cardioprotective effect of lamotr. after focal ischemia in rats. Stroke 1995 PMID: 7839380
Leach Neurochemical and behavioral aspects of lamotr. Epilepsia 1991 PMID: 1685439

Citations for Lamotrigine isethionate (1)

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Citations are publications that use Bio-Techne products. Selected citations for Lamotrigine isethionate include:

Madry et al. (2018) Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron. 97:299
PMID: 29290552

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