Simvastatin

Tocris Bioscience, part of Bio-Techne | Catalog # 1965

HMG-CoA reductase inhibitor
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Key Product Details

Description

HMG-CoA reductase inhibitor

View all HMG-CoA Reductase Inhibitors »

Product Description

Simvastatin is a HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Simvastatin is also an AMPK activator. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, inhibition of autophagy, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.Simvastatin acts synergistically with ABL allosteric inhibitors GNF 5 (Cat. No. 1965) to enhance apoptosis of metastatic lung cancer cells in mice.

Product Specifications

Molecular Weight

418.57

Formula

C25H38O5

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate

CAS Number

79902-63-9

PubChem ID

54454

InChI Key

RYMZZMVNJRMUDD-HGQWONQESA-N

SMILES

[H][C@@]12C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(O3)=O)=C[C@H](C)C[C@@H]1OC(C(C)(C)CC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.93 50
Ethanol 31.39 75

Preparing Stock Solutions for Simvastatin

The following data is based on the product molecular weight 418.57

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 3.19 mL 15.93 mL 31.85 mL
3.75 mM 0.64 mL 3.19 mL 6.37 mL
7.5 mM 0.32 mL 1.59 mL 3.19 mL
37.5 mM 0.06 mL 0.32 mL 0.64 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Simvastatin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Simvastatin

For research use only

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