SHU 9119

Name: SHU 9119
Brand: Tocris Bioscience
SKU: 3420

Tocris Bioscience, part of Bio-Techne | Catalog # 3420

Citations (46)

COA / SDS

MC3 and MC4 antagonist; MC5 partial agonist

Key Product Details

Description:	MC₃ and MC₄ antagonist; MC₅ partial agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1074.25

View Full Technical Details for SHU 9119

Technical Data
Citations

Biological Activity for SHU 9119

SHU 9119 is a potent melanocortin MC₃ and MC₄ receptor antagonist (IC₅₀ values are 0.23 and 0.06 nM respectively) and MC₅ partial agonist (EC₅₀ = 0.12 nM). Upregulates expression of genes promoting lipogenesis and triglyceride storage (SCD1, LPL, ACCα and FAS), increases triglyceride synthesis and promotes insulin resistance. Increases food intake, body weight and fat mass when administered centrally in vivo.

Technical Data for SHU 9119

M. Wt	1074.25
Formula	C₅₄H₇₁N₁₅O₉
Single Letter Sequence	XDHXRWK (Modifications: X-1 = Ac-Nle, X-4 = D-2-Nal, Lys-7 = C-terminal amide, cyclized Asp-2 - Lys-7)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	168482-23-3
PubChem ID	9898183
InChi Key	GGYWLZFXFKFWKL-XOJVSUSESA-N
Smiles	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SHU 9119

Solubility

Soluble to 0.2mg/ml in water

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References for SHU 9119

References are publications that support the biological activity of the product.

Grieco Further structure-activity studies with lactam derivatives of MT-II and SHU-9119: Their activity and selectivity at human melanocortin receptors 3, 4 and 5. Peptides 2007 PMID: 17482720
Nogueiras The central melanocortin system directly controls peripheral lipid metabolism. J.Clin.Invest. 2007 PMID: 17885689
Hruby Cyclic lactam α-melanotropin analogues of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10] a-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency a J.Med.Chem. 1995 PMID: 7658432