SHU 9119
Tocris Bioscience, part of Bio-Techne | Catalog # 3420
MC3 and MC4 antagonist; MC5 partial agonist
Key Product Details
Description
MC3 and MC4 antagonist; MC5 partial agonist
Product Description
SHU 9119 is a potent melanocortin MC3 and MC4 receptor antagonist (IC50 values are 0.23 and 0.06 nM respectively) and MC5 partial agonist (EC50 = 0.12 nM). Upregulates expression of genes promoting lipogenesis and triglyceride storage (SCD1, LPL, ACCα and FAS), increases triglyceride synthesis and promotes insulin resistance. Increases food intake, body weight and fat mass when administered centrally in vivo.Product Specifications
Molecular Weight
1074.25
Formula
C54H71N15O9
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
168482-23-3
PubChem ID
9898183
InChI Key
GGYWLZFXFKFWKL-XOJVSUSESA-N
SMILES
CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 0.2mg/ml in water |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Grieco Further structure-activity studies with lactam derivatives of MT-II and SHU-9119: Their activity and selectivity at human melanocortin receptors 3, 4 and 5. Peptides 2007 PMID: 17482720
- Nogueiras The central melanocortin system directly controls peripheral lipid metabolism. J.Clin.Invest. 2007 PMID: 17885689
- Hruby Cyclic lactam α-melanotropin analogues of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10] a-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency a J.Med.Chem. 1995 PMID: 7658432
Product Specific Notices for SHU 9119
For research use only
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