SB 612111 hydrochloride

Name: SB 612111 hydrochloride
Brand: Tocris Bioscience
SKU: 3573

Catalog # 3573 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

Selective NOP antagonist

Key Product Details

Description:	Selective NOP antagonist
Chemical Name:	(5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	454.86

View Full Technical Details for SB 612111 hydrochloride

Technical Data
Citations (2) / Reviews

Biological Activity for SB 612111 hydrochloride

SB 612111 hydrochloride is a selective NOP receptor antagonist (K_i values are 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors respectively). Antagonizes the pronociceptive action of nociceptin (Cat. No. 0910) in an acute pain model. Potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model.

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries for SB 612111 hydrochloride

SB 612111 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SB 612111 hydrochloride

M. Wt	454.86
Formula	C₂₄H₂₉Cl₂NO.HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
PubChem ID	21061234
InChi Key	DCKUVQADDNMWEF-DQFHVVJASA-N
Smiles	CC1=CC=CC2=C1CC[C@H](CN3CCC(C4=C(Cl)C=CC=C4Cl)CC3)C[C@@H]2O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 612111 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.49	100
	ethanol	22.74	50

Preparing Stock Solutions for SB 612111 hydrochloride

The following data is based on the product molecular weight 454.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	10.99 mL	21.98 mL
5 mM	0.44 mL	2.20 mL	4.40 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for SB 612111 hydrochloride

References are publications that support the biological activity of the product.

Rizzi Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies. J.Pharmacol.Exp.Ther. 2007 PMID: 17329551
Spagnolo Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies. J.Pharm.Exp.Ther.
Zaratin Modification of nociception and mor. tolerance by the selective opiate receptor-like orphan receptor antagonist (-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111) J.Pharmacol.Exp.Ther. 2004 PMID: 14593080

Citations for SB 612111 hydrochloride (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for SB 612111 hydrochloride include:

Michael R et al. (2019) Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists. Sci Signal. 12
PMID: 30914485
Hardaway et al. (2016) Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating. Behav Brain Res. 307:25
PMID: 27036650

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