Nociceptin

Name: Nociceptin
Brand: Tocris Bioscience
SKU: 0910

Tocris Bioscience a Bio-Techne Brand

Catalog # 0910

Citations (16)

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Key Product Details

Description:	Endogenous NOP agonist
Alternative Names:	Orphanin FQ
Purity:	≥95% (HPLC)
Molecular Weight:	1809

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Biological Activity for Nociceptin

Nociceptin is an endogenous ligand for the NOP opioid receptor (pK_i = 8.6). Has no significant activity at μ, δ or κ opioid receptors (pK_i

Technical Data for Nociceptin

M. Wt	1809
Formula	C₇₉H₁₂₉N₂₇O₂₂
Single Letter Sequence	FGGFTGARKSARKLANQ
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	170713-75-4
PubChem ID	16131448
InChi Key	PULGYDLMFSFVBL-SMFNREODSA-N
Smiles	[H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nociceptin

Solubility

Soluble to 1mg/ml in water

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References for Nociceptin

References are publications that support the biological activity of the product.

Guerrini Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A. Peptides 2000 PMID: 10998526
Henderson and McKnight The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. TiPS 1997 PMID: 9277133
Reinscheid Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor. Science 1995 PMID: 7481766
Meunier Isolation and structure of the endogenous agonist of opioid receptor-like ORL₁ receptor. Nature 1995 PMID: 7566152

Citations for Nociceptin (16)

Showing 1 - 10 of 16 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Nociceptin include:

Wang et al. (2019) Nociceptin Receptor Is Overexpressed in Non-small Cell Lung Cancer and Predicts Poor Prognosis. Front Oncol. 9:235
PMID: 31024840
Fox and Hentges (2017) Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity. J Neurosci. 37:8667
PMID: 28821664
Schmid et al. (2017) Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell. 171:1165
PMID: 29149605
Wang et al. (2015) Bupren.-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors. Psychopharmacology (Berl). 19:2587
PMID: 26153065
Kelly et al. (2015) The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours. Neurochem Res. 232:305
PMID: 24973897
Farrag et al. (2015) Modulation of voltage-gated Ca2+ channels by G protein-coupled receptors in celiac-mesenteric ganglion neurons of septic rats. BMC Complement Altern Med. 10:e0125566
PMID: 26017846
McIlwrath and Westlund (2015) Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. J Cell Mol Med. 21:836
PMID: 25624717
Popiolek-Barczyk et al. (2014) MinCyc enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain. Biomed Res Int. 2014:762930
PMID: 25276817
Kallupi et al. (2014) Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats. Neuropsychopharmacology. 39:1081
PMID: 24169802
Miranda-Morales et al. (2013) Participation of the nociceptin/orphanin FQ receptor in ethanol-mediated locomotor activation and ethanol intake in preweanling rats. Behav Brain Res. 245:137
PMID: 23439216
Lee et al. (2011) Differential pharmacological actions of meth. and Bupren. in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors. PLoS One. 36:2008
PMID: 21671107
Kokkola et al. (2005) S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner. BMC Cell Biol. 6:21
PMID: 15850493
Kuzmin et al. (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol. 141:132
PMID: 14662736
McLeod et al. (2001) Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors. World J Gastroenterol. 132:1175
PMID: 11250866
Werthwein et al. (1999) Further characterization of the ORL1 receptor-mediated inhibition of noradrenaline release in the mouse brain in vitro. Br J Pharmacol. 127:300
PMID: 10369486
Giuliani and Maggi (1996) Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide. Br J Pharmacol. 118:1567
PMID: 8842416

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