SB 525334

Name: SB 525334
Brand: Tocris Bioscience
SKU: 3211

Tocris Bioscience a Bio-Techne Brand

Catalog # 3211

Citations (7)

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Key Product Details

Description:	Selective inhibitor of TGF-βRI
Chemical Name:	6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
Purity:	≥97% (HPLC)
Molecular Weight:	343.42

View Full Technical Details for SB 525334

Biological Activity for SB 525334

SB 525334 is a selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC₅₀ = 14.3 nM). Inhibits TGF-β1-induced smad2/3 nuclear localization and TGF-βRI-induced mRNA expression in kidney cells. Attenuates bleomycin-induced pulmonary fibrosis.

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries for SB 525334

SB 525334 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for SB 525334

M. Wt	343.42
Formula	C₂₁H₂₁N₅
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	356559-20-1
PubChem ID	9967941
InChi Key	DKPQHFZUICCZHF-UHFFFAOYSA-N
Smiles	CC1=NC(C4=C(NC(C(C)(C)C)=N4)C2=CC=C(N=CC=N3)C3=C2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SB 525334

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.34	100
	1eq. HCl	34.34	100

Preparing Stock Solutions for SB 525334

The following data is based on the product molecular weight 343.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.91 mL	14.56 mL	29.12 mL
5 mM	0.58 mL	2.91 mL	5.82 mL
10 mM	0.29 mL	1.46 mL	2.91 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for SB 525334

References are publications that support the biological activity of the product.

Higashiyama Inhibition of AVNreceptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis Exp.Mol.Pathol. 2007 PMID: 17274978
Laping Tumor-specific efficacy of transforming growth factor-βRI inhibition in eker rats. Clin.Cancer Res. 2007 PMID: 17505012
Grygielko Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-β type I receptor kinase in puromycin-induced nephritis. J.Pharmacol.Exp.Ther. 2005 PMID: 15769863

Citations for SB 525334 (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for SB 525334 include:

Kilari et al. (2018) Increased transforming growth factor beta (TGF-β) and pSMAD3 signaling in a Murine Model for Contrast Induced Kidney Injury. Sci Rep. 8:6630
PMID: 29700311
Kleczko et al. (2015) An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases. PLoS One. 10:e0123600
PMID: 25946135
Gutiérrez et al. (2015) RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice. Lab Chip. 10:e0135005
PMID: 26247610
Grygielewicz et al. (2014) Epithelial-mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells. Gastric Cancer. 2014;
PMID: 25407459
Denby et al. (2014) MicroRNA-214 antagonism protects against renal fibrosis. J Am Soc Nephrol. 25:65
PMID: 24158985
Li et al. (2013) Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments. Sci Rep. 13:1969
PMID: 23563587
Ng et al. (2012) Progenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors. Clin Cancer Res. 18:4122
PMID: 22675171

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