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SB 239063

Tocris Bioscience a Bio-Techne Brand

p38 Inhibitors Small Molecule
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1962/10
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Key Product Details

Description: Potent, selective p38 MAPK inhibitor; orally active
Chemical Name: trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol
Purity: ≥98% (HPLC)
Molecular Weight: 368.41

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Citations for SB 239063 (8)

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  • The role of p38 MAPK signaling in LPA induced pro-inflammatory phenotype in microglia cells
    Name: Joanna Plastira
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Primary murine microglia cells
    The role of MAPK pathways (JNK, p38 and ERK) was studied in the LPA induced pro-inflammatory phenotype in microglia. In this case cells were incubated for the indicated time points with LPA (1µM) in the presence or absence of SB239063 (10µM) or SB203580 (10µM). A series of assays were performed. p38 MAPK inhibition totally decreased the expression of 4 pro-inflammatory transcription factors (here presented: pp65). Both inhibitors worked nicely and the results were consistent.
    SB 239063 Serum 1962

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Product Documents for SB 239063

Certificate of Analysis

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