(S)-(-)-Propranolol hydrochloride

Name: ( S )-(-)-Propranolol hydrochloride
Brand: Tocris Bioscience
SKU: 0834

Catalog # 0834

Citations (1)

COA / SDS

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Key Product Details

Description:	β antagonist. More active enantiomer of propranolol (Cat. No. 0624)
Chemical Name:	(S)-(-)-1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	295.81

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Biological Activity

(S)-(-)-Propranolol hydrochloride is a more active enantiomer of the β-adrenoceptor antagonist propranolol.

Racemate, R-enantiomer and Glycol Metabolite also available.

Technical Data

M. Wt	295.81
Formula	C₁₆H₂₁NO₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	4199-10-4
PubChem ID	165193
InChi Key	ZMRUPTIKESYGQW-UQKRIMTDSA-N
Smiles	CC(C)NC[C@]([H])(O)COC2=CC=CC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 295.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.38 mL	16.90 mL	33.81 mL
5 mM	0.68 mL	3.38 mL	6.76 mL
10 mM	0.34 mL	1.69 mL	3.38 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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References

References are publications that support the biological activity of the product.

Barrett The biological properties of the optical isomers of propra. and their effects on cardiac arrhythmias. Br.J.Pharmacol. 1968 PMID: 19108278
Bond Metabolism of propra. (Inderal) a potent, specific β-adrenergic receptor blocking agent. Nature 1967 PMID: 6031788

Citations for (<em>S</em>)-(-)-Propranolol hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for (S)-(-)-Propranolol hydrochloride include:

Kaya et al. (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. Br J Pharmacol. 329:350
PMID: 19144685

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