Key Product Details
Description: | Highly selective CCR2 chemokine receptor antagonist |
Chemical Name: | 6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 417.5 |
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Citations for RS 504393 (15)
Citations are publications that use Bio-Techne products. Selected citations for RS 504393 include:
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Linde
(2018)
Macrophages orchestrate breast cancer early dissemination and metastasis.
Nat Commun.
9(1):21
PMID: 29295986 -
Tong et al.
(2018)
Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production.
EBioMedicine.
2018;
PMID: 30528455 -
Kwiatkowski et al.
(2017)
The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats.
J Neuroimmune Pharmacol.
2017;
PMID: 28337574 -
Lourenco et al.
(2015)
Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
J Immunol.
194:3463
PMID: 25712213 -
Mazumdar et al.
(2015)
CoREST1 Promotes Tumor Formation and Tumor Stroma Interactions in a Mouse Model of Breast Cancer.
PLoS One.
10:e0121281
PMID: 25793264 -
Ayoub et al.
(2015)
Functional Interaction between Angiotensin II Receptor Type 1 and Chemokine (C-C Motif) Receptor 2 with Implications for Chronic Kidney Disease.
PLoS One.
10:e0119803
PMID: 25807547 -
Lu et al.
(2015)
Inhibiting the mobilization of Ly6C(high) monocytes after acute myocardial infarction enhances the efficiency of mesenchymal stromal cell transplantation and curbs myocardial remodeling.
J Neurosci.
7:587
PMID: 26045897 -
Matsubara et al.
(2015)
Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity.
Cancer Res.
35:2452
PMID: 25673840 -
Kim et al.
(2014)
IL-33-induced hematopoietic stem and progenitor cell mobilization depends upon CCR2.
J Immunol.
193:3792
PMID: 25143444 -
Arms et al.
(2013)
Expression and function of CCL2/CCR2 in rat micturition reflexes and somatic sensitivity with urinary bladder inflammation.
Am J Physiol Renal Physiol.
305:F111
PMID: 23594826 -
Arendt et al.
(2013)
Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis.
J Biol Chem.
73:6080
PMID: 23959857 -
Zhang et al.
(2012)
Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain.
J Neuroinflammation.
9:136
PMID: 22721162 -
Miller et al.
(2012)
CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis.
Proc Natl Acad Sci U S A.
109:20602
PMID: 23185004 -
Simonson and Ismail-Beigi
(2011)
Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop.
Br J Pharmacol.
286:11003
PMID: 21169360 -
Yang et al.
(2009)
Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy.
Diabetologia.
52:972
PMID: 19277603
There are no citations that match your criteria.
Customer Reviews for RS 504393 (1)
Customer Images
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Species: HumanAssay Type: In VitroCell Line/Tissue: A549 or MDAMB231Receptor antagonists (SB225002: for CXCR2, AMD3465: for CXCR4, RS504393: for CCR2 and Maraviroc: for CCR5) at 10 μMWe ordered this product, combining with another inhibitor, to confirm the migration.To confirm that tested product induces migration, we also screen all MAPK inhibitors and MIF receptor antagonists
There are no reviews that match your criteria.