Rostafuroxin
Tocris Bioscience, part of Bio-Techne | Catalog # 5315
Na+/K+ ATPase modulator; antihypertensive agent
Key Product Details
Description
Na+/K+ ATPase modulator; antihypertensive agent
Alternative Names
PST 2238
Product Description
Rostafuroxin is a Na+/K+ ATPase modulator. Inhibits the Normalizes renal Na+/K+ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypertensive rats. Controls mania-like behaviors in Myshkin mice having a Na+/K+ ATPase α3 subunit mutation. Antagonizes the effects of Ouabain (Cat.No. 1076) on myogenic tone and Ca2+ signaling in rat hippocampal neurons.Product Specifications
Molecular Weight
374.51
Formula
C23H34O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3β,5β,14β)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol
CAS Number
156722-18-8
PubChem ID
153976
InChI Key
AEAPORIZZWBIEX-DTBDINHYSA-N
SMILES
O[C@]4(C5=COC=C5)CC[C@]3(O)[C@]2([H])CC[C@]1([H])C[C@@H](O)CC[C@@](C)1[C@]([H])2CC[C@@]34C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.45 | 100 | |
| Ethanol | 37.45 | 100 |
Preparing Stock Solutions
for Rostafuroxin
The following data is based on the product molecular weight 374.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.35 mL | 26.70 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.34 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Song Ouabain-digoxin antagonism in rat arteries and neurones. J.Physiol. 2014 PMID: 24344167
- Kirshenbaum Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump. Proc.Natl.Acad.Sci.U.S.A. 2011 PMID: 22025725
- Ferrari Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension. Biochim Biophys Acta. 2010 PMID: 20083196
- Ferrari Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am.J.Physiol.Regul.Integr.Comp.Physiol. 2006 PMID: 16467500
Product Specific Notices for Rostafuroxin
For research use only
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