Ouabain
Tocris Bioscience, part of Bio-Techne | Catalog # 1076
Na+/K+ ATPase inhibitor
Product Description
Ouabain is a selective Na+, K+-ATPase inhibitor. Cardiotonic agent. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.08 μM).Product Specifications
Molecular Weight
584.66
Formula
C29H44O12
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide
CAS Number
630-60-4
PubChem ID
439501
InChI Key
LPMXVESGRSUGHW-MJARETDLSA-N
SMILES
O[C@@]12[C@@]3([H])[C@]([C@]([C@H](O)C[C@H](O[C@H]4C(O)C(O)[C@@H](O)[C@H](C)O4)C5)(CO)[C@]5(O)CC3)([H])[C@H](O)C[C@]1(C)[C@@H](C(CO6)=CC6=O)CC2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 10 | ||
| DMSO | 58.47 | 100 |
Preparing Stock Solutions
for Ouabain
The following data is based on the product molecular weight 584.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.71 mL | 8.55 mL | 17.10 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 10 mM | 0.17 mL | 0.86 mL | 1.71 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ko Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. BioRxiv - Paper not yet peer reviewed
- Hosoi Isoform-specific up-regulation by ouabain of Na+, K+-ATPase in cultured rat astrocytes. J.Neurochem. 1997 PMID: 9349566
- Marjorie Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9272726
- Croyle Extensive random mutagenesis analysis of the Na/K+ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding. Eur.J.Biochem. 1997 PMID: 9346307
Product Specific Notices for Ouabain
For research use only
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