Ro 64-5229
Tocris Bioscience, part of Bio-Techne | Catalog # 2913
Selective, non-competitive mGlu2 antagonist
Key Product Details
Description
Selective, non-competitive mGlu2 antagonist
Product Description
Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. Inhibits GTPγ35S binding to mGlu2-containing membranes (IC50 = 0.11 μM).Product Specifications
Molecular Weight
352.26
Formula
C17H19Cl2N3O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole
CAS Number
246852-46-0
PubChem ID
10428048
InChI Key
STCVFKBRXOEQRF-YBEGLDIGSA-N
SMILES
ClC1=CC=CC(Cl)=C1/C(OC3CCCCCC3)=C/N2N=CN=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.23 | 100 | |
| Ethanol | 35.23 | 100 |
Preparing Stock Solutions
for Ro 64-5229
The following data is based on the product molecular weight 352.26
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.84 mL | 14.19 mL | 28.39 mL |
| 5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.84 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brauner-Osbourne Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Curr.Drug Targets. 2007 PMID: 17266540
- Kolczewski Synthesis of heterocyclic enol ethers and their use as a group 2 metabotropic glutamate receptor antagonists. Bioorg.Med.Chem.Lett. 1999 PMID: 10465539
Product Specific Notices for Ro 64-5229
For research use only
Loading...
Loading...