Reparixin L-lysine salt

Name: Reparixin L-lysine salt
Brand: Tocris Bioscience
SKU: 6957

Tocris Bioscience, part of Bio-Techne | Catalog # 6957

COA / SDS

Potent CXCR1 and CXCR2 allosteric antagonist

Discontinued Product

6957 has been discontinued. View all Chemokine Receptor Antagonists products.

Key Product Details

Description:	Potent CXCR1 and CXCR2 allosteric antagonist
Alternative Names:	Repertaxin L-lysine salt
Chemical Name:	(αR)-α-Methyl-4-(2-methylpropyl)-N-(methylsulfonyl)benzeneacetamide L-Lysine salt
Purity:	≥98% (HPLC)
Molecular Weight:	429.58

View Full Technical Details for Reparixin L-lysine salt

Technical Data
Citations

Biological Activity for Reparixin L-lysine salt

Reparixin L-lysine salt is a potent and noncompetitive CXCR1 and CXCR2 allosteric antagonist (IC₅₀ = 1 nM for inhibition of CXCL8-induced human polymorphonuclear cell migration). Also inhibits migration of rodent neutrophils induced by CXCL1, CXCL2, CXCL8 and CINC-1. Inhibits vascular permeability and neutrophil recruitment in in vivo models of mild and severe ischemia/reperfusion injury. Also selectively depletes cancer stem cells in human breast cancer cell lines and xenograft models.

Technical Data for Reparixin L-lysine salt

M. Wt	429.58
Formula	C₁₄H₂₁NO₃S.C₆H₁₄N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	266359-93-7
PubChem ID	9932389
InChi Key	JEJFWWFZAQBZMJ-GVKMLHTLSA-N
Smiles	NCCCC[C@H](N)C(O)=O.CC(C)CC1=CC=C(C=C1)[C@@H](C)C(=O)N[S](C)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Reparixin L-lysine salt

References are publications that support the biological activity of the product.

Souza Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury. Br.J.Pharmacol. 2004 PMID: 15302676
Ginestier CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J.Clin.Invest. 2010 PMID: 20051626
Bertini Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc.Natl.Acad.Sci.U.S.A. 2004 PMID: 15282370

Reparixin L-lysine salt

Tocris Bioscience, part of Bio-Techne | Catalog # 6957

Key Product Details

Biological Activity for Reparixin L-lysine salt

Technical Data for Reparixin L-lysine salt

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Reparixin L-lysine salt

Product Documents for Reparixin L-lysine salt

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected