Reparixin L-lysine salt
Tocris Bioscience, part of Bio-Techne | Catalog # 6957
Potent CXCR1 and CXCR2 allosteric antagonist
Discontinued Product
6957 has been discontinued.
View all Chemokine Receptor Antagonists products.
Key Product Details
Description
Potent CXCR1 and CXCR2 allosteric antagonist
Alternative Names
Repertaxin L-lysine salt
Product Description
Reparixin L-lysine salt is a potent and noncompetitive CXCR1 and CXCR2 allosteric antagonist (IC50 = 1 nM for inhibition of CXCL8-induced human polymorphonuclear cell migration). Also inhibits migration of rodent neutrophils induced by CXCL1, CXCL2, CXCL8 and CINC-1. Inhibits vascular permeability and neutrophil recruitment in in vivo models of mild and severe ischemia/reperfusion injury. Also selectively depletes cancer stem cells in human breast cancer cell lines and xenograft models.Product Specifications
Molecular Weight
429.58
Formula
C14H21NO3S.C6H14N2O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(αR)-α-Methyl-4-(2-methylpropyl)-N-(methylsulfonyl)benzeneacetamide L-Lysine salt
CAS Number
266359-93-7
PubChem ID
9932389
InChI Key
JEJFWWFZAQBZMJ-GVKMLHTLSA-N
SMILES
NCCCC[C@H](N)C(O)=O.CC(C)CC1=CC=C(C=C1)[C@@H](C)C(=O)N[S](C)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.15 | 5 with gentle warming | |
| DMSO | 21.48 | 50 |
Preparing Stock Solutions
for Reparixin L-lysine salt
The following data is based on the product molecular weight 429.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.66 mL | 23.28 mL | 46.56 mL |
| 2.5 mM | 0.93 mL | 4.66 mL | 9.31 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
| 25 mM | 0.09 mL | 0.47 mL | 0.93 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Souza Repertaxin, a novel inhibitor of rat CXCR2 function, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury. Br.J.Pharmacol. 2004 PMID: 15302676
- Ginestier CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J.Clin.Invest. 2010 PMID: 20051626
- Bertini Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc.Natl.Acad.Sci.U.S.A. 2004 PMID: 15282370
Product Specific Notices for Reparixin L-lysine salt
For research use only
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