(R)-(-)-Rolipram

Name: ( R )-(-)-Rolipram
Brand: Tocris Bioscience
SKU: 1349

Tocris Bioscience, part of Bio-Techne | Catalog # 1349

Citations (15)

COA / SDS

PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)

Key Product Details

Description:	PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)
Chemical Name:	(4R)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	275.35

View Full Technical Details for (R)-(-)-Rolipram

Technical Data
Citations

Biological Activity for (R)-(-)-Rolipram

(R)-(-)-Rolipram is a more active enantiomer of the PDE4 inhibitor rolipram; 2-10-fold more potent than the S-(+) enantiomer.

Racemate and S-enantiomer also available.

Compound Libraries for (R)-(-)-Rolipram

(R)-(-)-Rolipram is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (R)-(-)-Rolipram

M. Wt	275.35
Formula	C₁₆H₂₁NO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	85416-75-7
PubChem ID	448055
InChi Key	HJORMJIFDVBMOB-LBPRGKRZSA-N
Smiles	O=C1NC[C@@H](C2=CC(OC3CCCC3)=C(OC)C=C2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-(-)-Rolipram

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	27.54	100
	DMSO	27.54	100

Preparing Stock Solutions for (R)-(-)-Rolipram

The following data is based on the product molecular weight 275.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.63 mL	18.16 mL	36.32 mL
5 mM	0.73 mL	3.63 mL	7.26 mL
10 mM	0.36 mL	1.82 mL	3.63 mL
50 mM	0.07 mL	0.36 mL	0.73 mL

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Reconstitution Calculator

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References for (R)-(-)-Rolipram

References are publications that support the biological activity of the product.

Owens Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells. Biochem.J. 1997 PMID: 9337850
Schneider Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur.J.Pharmacol. 1986 PMID: 3019721
Ohsawa Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. Jpn.J.Pharmacol. 1998 PMID: 9681571