(R)-(+)-8-Hydroxy-DPAT hydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 1080
Selective 5-HT1A agonist; enantiomer of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529)
Discontinued Product
1080 has been discontinued.
View all 5-HT1 Receptor Agonists products.
Key Product Details
Description
Selective 5-HT1A agonist; enantiomer of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529)
Product Description
(R)-(+)-8-Hydroxy-DPAT hydrobromide is a full 5-HT1A serotonin receptor agonist. Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. More active enantiomer of 8-Hydroxy-DPAT hydrobromide.Racemate and 7-Hydroxy Isomer also available.
Product Specifications
Molecular Weight
328.29
Formula
C16H25NO.HBr
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide
CAS Number
78095-19-9
PubChem ID
11957570
InChI Key
BATPBOZTBNNDLN-PFEQFJNWSA-N
SMILES
Br.CCCN(CCC)[C@@H]1CCC2=CC=CC(O)=C2C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 24.62 | 75 | |
| DMSO | 24.62 | 75 |
Preparing Stock Solutions
for (R)-(+)-8-Hydroxy-DPAT hydrobromide
The following data is based on the product molecular weight 328.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 4.06 mL | 20.31 mL | 40.61 mL |
| 3.75 mM | 0.81 mL | 4.06 mL | 8.12 mL |
| 7.5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 37.5 mM | 0.08 mL | 0.41 mL | 0.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Corrfield Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogues at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Mol.Pharmacol. 1991 PMID: 1828859
- Yoshitake and Kehr Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 2004 PMID: 15050424
- Bjork Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain. J.Med.Chem. 1989 PMID: 2522991
Product Specific Notices for (R)-(+)-8-Hydroxy-DPAT hydrobromide
For research use only
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