PSNCBAM-1

Name: PSNCBAM-1
Brand: Tocris Bioscience
SKU: 5321
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5321

(1)

Citations (2)

COA / SDS

Negative allosteric modulator of CB1 receptors

Key Product Details

Description:	Negative allosteric modulator of CB₁ receptors
Chemical Name:	N-(4-Chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]urea
Purity:	≥98% (HPLC)
Molecular Weight:	392.88

View Full Technical Details for PSNCBAM-1

Technical Data
Citations / Reviews (1)

Biological Activity for PSNCBAM-1

PSNCBAM-1 is a CB₁ receptor negative allosteric modulator (IC₅₀ values are 45 and 209 nM for the inhibition of CP 55,940 and WIN 55,212-2 respectively). Has no effect at the CB₂ receptor. Decreases food intake and body weight in rats.

Compound Libraries for PSNCBAM-1

PSNCBAM-1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PSNCBAM-1

M. Wt	392.88
Formula	C₂₂H₂₁ClN₄O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	877202-74-9
PubChem ID	11560249
InChi Key	HDAYFSFWIPRJSO-UHFFFAOYSA-N
Smiles	ClC1=CC=C(NC(NC2=CC(C3=CC=CC(N4CCCC4)=N3)=CC=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PSNCBAM-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.29	100

Preparing Stock Solutions for PSNCBAM-1

The following data is based on the product molecular weight 392.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.73 mL	25.45 mL
5 mM	0.51 mL	2.55 mL	5.09 mL
10 mM	0.25 mL	1.27 mL	2.55 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for PSNCBAM-1

References are publications that support the biological activity of the product.

German Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). J.Med.Chem. 2014 PMID: 25162172
Horswill PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB₁ receptors with hypophagic effects in rats. Br.J.Pharmacol. 2007 PMID: 17592509