WIN 55,212-2 mesylate is a selective high affinity CB₂ agonist (K_i values are 3.3 and 62.3 nM at the human cloned CB₂ and CB₁ receptors respectively).

Product Specifications

Molecular Weight

522.61

Formula

C₂₇H₂₆N₂O₃.CH₃SO₃H

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate

CAS Number

131543-23-2

PubChem ID

6604176

InChI Key

FSGCSTPOPBJYSX-VEIFNGETSA-N

SMILES

CS(O)(=O)=O.CC1=C(C(=O)C2=CC=CC3=C2C=CC=C3)C2=CC=CC3=C2N1[C@H](CN1CCOCC1)CO3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	52.26	100 with gentle warming
	Ethanol	15.68	30 with gentle warming

Preparing Stock Solutions for WIN 55,212-2 mesylate

The following data is based on the product molecular weight 522.61

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.91 mL	9.57 mL	19.13 mL
5 mM	0.38 mL	1.91 mL	3.83 mL
10 mM	0.19 mL	0.96 mL	1.91 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Martellotta Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug naive mice. Neuroscience 1998 PMID: 9622233
Felder Comparison of the pharmacology and signal transduction of the human cannabinoid CB₁ and CB₂ receptors. Mol.Pharmacol. 1995 PMID: 7565624
Griffin Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes. J.Pharmacol.Exp.Ther. 1998 PMID: 9580597
D'Ambra Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor. J.Med.Chem. 1992 PMID: 1732519

WIN 55,212-2 mesylate

Tocris Bioscience, part of Bio-Techne | Catalog # 1038

Key Product Details

Description

Alternative Names

View all Non-selective Cannabinoid Receptor Agonists »

Product Description