WIN 55,212-2 mesylate

Name: WIN 55,212-2 mesylate
Brand: Tocris Bioscience
SKU: 1038

Tocris Bioscience, part of Bio-Techne | Catalog # 1038

Citations (79)

COA / SDS

Selective high affinity CB2 agonist

Key Product Details

Description:	Selective high affinity CB₂ agonist
Alternative Names:	(R)-(+)-WIN 55212
Chemical Name:	(R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate
Purity:	≥98% (HPLC)
Molecular Weight:	522.61

View Full Technical Details for WIN 55,212-2 mesylate

Technical Data
Citations

Biological Activity for WIN 55,212-2 mesylate

WIN 55,212-2 mesylate is a selective high affinity CB₂ agonist (K_i values are 3.3 and 62.3 nM at the human cloned CB₂ and CB₁ receptors respectively).

Technical Data for WIN 55,212-2 mesylate

M. Wt	522.61
Formula	C₂₇H₂₆N₂O₃.CH₃SO₃H
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	131543-23-2
PubChem ID	6604176
InChi Key	FSGCSTPOPBJYSX-VEIFNGETSA-N
Smiles	CS(O)(=O)=O.CC1=C(C(=O)C2=CC=CC3=C2C=CC=C3)C2=CC=CC3=C2N1[C@H](CN1CCOCC1)CO3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WIN 55,212-2 mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	15.68	30 with gentle warming
	DMSO	52.26	100 with gentle warming

Preparing Stock Solutions for WIN 55,212-2 mesylate

The following data is based on the product molecular weight 522.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.91 mL	9.57 mL	19.13 mL
5 mM	0.38 mL	1.91 mL	3.83 mL
10 mM	0.19 mL	0.96 mL	1.91 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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Reconstitution Calculator

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References for WIN 55,212-2 mesylate

References are publications that support the biological activity of the product.

Martellotta Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug naive mice. Neuroscience 1998 PMID: 9622233
Felder Comparison of the pharmacology and signal transduction of the human cannabinoid CB₁ and CB₂ receptors. Mol.Pharmacol. 1995 PMID: 7565624
Griffin Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes. J.Pharmacol.Exp.Ther. 1998 PMID: 9580597
D'Ambra Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor. J.Med.Chem. 1992 PMID: 1732519