WIN 55,212-2 mesylate

Citations are publications that use Bio-Techne products. Selected citations for WIN 55,212-2 mesylate include:

• Pedersen et al. (2021) A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors J Biol Chem. 296:100503
  PMID: 33684444
• Diniz et al. (2019) Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors. PeerJ. 7:e6493
  PMID: 30809460
• Xiao et al. (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife. 7
  PMID: 29676731
• Tan and Cao (2018) Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons. Int J Mol Med. 42:919
  PMID: 29786105
• Hegyi et al. (2018) CB1 receptor activation induces intracellular Ca²⁺ mobilization and 2-arachidonoylglycerol release in rodent spinal cord astrocytes. Sci Rep. 8:10562
  PMID: 30002493
• Balleza-Tapia et al. (2018) TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro. Elife. 7
  PMID: 30417826
• Mouro et al. (2018) Chronic, intermittent treatment with a cannabinoid receptor agonist impairs recognition memory and brain network functional connectivity. J Neurochem. 147:71
  PMID: 29989183
• Khan et al. (2018) Involvement of the CB₂ cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma. BMC Cancer. 18:583
  PMID: 29792186
• Almada (2017) The synthetic cannabinoid WIN-55,212-55,212 induced-apoptosis in cytotrophoblasts cells by a mechanism dependent on CB1 receptor. Toxicology. 385:67
  PMID: 28495606
• Ford (2017) Characterization of structurally novel G protein biased CB1 agonists: implications for drug development. Pharmacol Res. 125:161
  PMID: 28838808
• Fatahi (2017) Involvement of cannabinoid system in the nucleus accumbens on delay-based decision making in the rat. Behav Brain Res.. 337:107
  PMID: 28987618
• Baker et al. (2017) Big conductance calcium-activated potassium channel openers control spasticity without sedation. Br J Pharmacol. 174:2662
  PMID: 28677901
• Hashimotodani et al. (2017) LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance. Neuron. 95:928
  PMID: 28817805
• Kruk-Slomka et al. (2016) Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands. Neural Plast. 2016:9815092
  PMID: 26839719
• Kong et al. (2016) Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1. Int J Neuropsychopharmacol. 13:4569
  PMID: 27082728
• Szücs et al. (2016) Decreased CB receptor binding and cannabinoid signaling in three brain regions of a rat model of schizophrenia Neuroscience Letters. 633:87
  PMID: 27639959
• Zou et al. (2016) Somatostatin receptor 5 is a prominent regulator of signaling pathways in cells with coexpression of Cannabinoid receptors 1 Neuroscience. 340:218
  PMID: 27984180
• Xian et al. (2016) WIN 55,212-2 inhibits the epithelial mesenchymal transition of gastric cancer cells via COX-2 signals Cell Physiology and Biochemistry. 39:2149
  PMID: 27802436
• Pinheiro et al. (2016) Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull. 124:222
  PMID: 27208730
• Seo et al. (2016) Regulation of divalent metal transporter-1 by serine phosphorylation. Biochem J. 473:4243
  PMID: 27681840
• Yu et al. (2016) Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy. Neurobiol Dis. 89:23
  PMID: 26804027
• Mahmoud et al. (2015) (4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229): a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs. Mol Pharmacol. 87:197
  PMID: 25411367
• Fanarioti et al. (2015) Behavioral and neurochemical changes in mesostriatal DArgic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55,212-2. Int J Mol Sci. 18
  PMID: 25522428
• Lin et al. (2015) Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. Sci Rep. 16:5555
  PMID: 25768340
• Gentry et al. (2015) TRPA1 mediates the hypothermic action of acetaminophen. Br J Pharmacol. 5:12771
  PMID: 26227887
• Flores-Otero et al. (2014) Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. Nat Commun. 5:4589
  PMID: 25081814
• Sánchez-Blázquez et al. (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Mol Med Rep. 17:1943
  PMID: 24485144
• Levin et al. (2014) Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain. Eur J Pharmacol. 5:10
  PMID: 24567721
• Tortoriello et al. (2014) Miswiring the brain: △9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway. Br J Pharmacol. 33:668
  PMID: 24469251
• Hruba and McMahon (2014) The cannabinoid agonist HU-210: pseudo-irreversible discriminative stimulus effects in rhesus monkeys. Neuropharmacology. 727:35
  PMID: 24486701
• Sreevalsan and Safe (2013) The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells. Mol Cancer Ther. 12:2483
  PMID: 24030632
• Li et al. (2013) Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis. Lab Invest. 93:322
  PMID: 23381627
• Marini et al. (2013) Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors. Br J Pharmacol. 169:887
  PMID: 23711022
• Abush and Akirav (2013) Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory. Neuropsychopharmacology. 38:1521
  PMID: 23426383
• Baillie et al. (2013) CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity. Mol Pharmacol. 83:322
  PMID: 23160940
• Caiati and Cherubini (2013) Fluoxetine impairs GABAergic signaling in hippocampal slices from neonatal rats. Front Cell Neurosci. 7:63
  PMID: 23641199
• Marcu et al. (2013) Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2. J Pharmacol Exp Ther. 345:189
  PMID: 23426954
• Prather et al. (2013) CB1 and CB2 receptors are novel molecular targets for tamox. and 4OH-Tamoxifen. Biochem Biophys Res Commun. 441:339
  PMID: 24148245
• Cawston et al. (2013) Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action. Br J Pharmacol. 170:893
  PMID: 23937487
• Uhelski et al. (2013) The non-selective cannabinoid receptor agonist WIN 55,212-2 attenuates responses of C-fiber nociceptors in a murine model of cancer pain. Neuroscience. 247:84
  PMID: 23673278
• Kargl et al. (2013) A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J Pharmacol Exp Ther. 346:54
  PMID: 23639801
• Akerman et al. (2013) Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and "triptan" receptors: implications in migraine. J Neurosci. 33:14869
  PMID: 24027286
• Caiati et al. (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep. 2:285
  PMID: 22368777
• Laricchiuta et al. (2012) CB1 receptor autoradiographic characterization of the individual differences in approach and avoidance motivation. PLoS One. 7:e42111
  PMID: 22848724
• Brents et al. (2012) Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity. Biochem Pharmacol. 83:952
  PMID: 22266354
• Liu et al. (2012) Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer. Mol Cancer Ther. 11:1421
  PMID: 22553354
• Segev et al. (2012) Stress hormones receptors in the amygdala mediate the effects of stress on the consolidation, but not the retrieval, of a non aversive spatial task. PLoS One. 7:e29988
  PMID: 22253850
• Giordano et al. (2012) TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception. Cereb Cortex. 22:2495
  PMID: 22139792
• Zhong et al. (2012) Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference. Neuropsychopharmacology. 37:2377
  PMID: 22713909
• Kargl et al. (2012) The cannabinoid receptor CB1 modulates the signaling properties of the lysophosphatidylinositol receptor GPR55. J Biol Chem. 287:44234
  PMID: 23161546
• Kazemi et al. (2012) Effect of cannabinoid receptor activation on spreading depression. Iran J Basic Med Sci. 15:926
  PMID: 23493641
• Sideris et al. (2012) A Role for the Cannabinoid 1 Receptor in Neuronal Differentiation of Adult Spinal Cord Progenitors in vitro is Revealed through Pharmacological Inhibition and Genetic Deletion. Front Neurosci. 6:4
  PMID: 22291615
• Abush and Akirav (2012) Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats. PLoS One. 7:e31731
  PMID: 22348124
• Izzo et al. (2012) Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. Br J Pharmacol. 166:1444
  PMID: 22300105
• Brents et al. (2011) Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity. PLoS One. 6:e21917
  PMID: 21755008
• Schicho et al. (2011) The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Inflamm Bowel Dis. 17:1651
  PMID: 21744421
• Preet et al. (2011) Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer Prev Res (Phila). 4:65
  PMID: 21097714
• Holderith et al. (2011) Cannabinoids attenuate hippocampal γ oscillations by suppressing excitatory synaptic input onto CA3 pyramidal neurons and fast spiking basket cells. J Neurosci. 589:4921
  PMID: 21859823
• Pan et al. (2011) Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice. J Cell Biol. 31:13420
  PMID: 21940435
• Tozzi et al. (2011) The distinct role of medium spiny neurons and cholinergic interneurons in the D2/A2A receptor interaction in the striatum: implications for Parkinson's disease. J Neurosci. 31:1850
  PMID: 21289195
• Tan et al. (2011) Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortex. J Neurosci. 31:5300
  PMID: 21471365
• Okada et al. (2011) High extracellular Ca2+ stimulates Ca2+-activated Cl- currents in frog parathyroid cells through the mediation of arachidonic acid cascade. PLoS One. 6:e19158
  PMID: 21559478
• Thompson and Perkel (2011) Endocannabinoids mediate synaptic plasticity at glutamatergic synapses on spiny neurons within a basal ganglia nucleus necessary for song learning. J Neurophysiol. 105:1159
  PMID: 21177997
• Sousa et al. (2011) Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory. Neuropsychopharmacology. 36:472
  PMID: 20927050
• Lecca et al. (2011) Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbrain DA cells. Neuropsychopharmacology. 36:589
  PMID: 21048703
• Wyeth et al. (2010) Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy. J Neurosci. 30:8993
  PMID: 20592220
• Kim and Alger (2010) Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. Nat Neurosci. 13:592
  PMID: 20348918
• Acuna-Goycolea et al. (2010) Cannabinoids excite circadian clock neurons. PLoS One. 30:10061
  PMID: 20668190
• Farkas et al. (2010) Retrograde endocannabinoid signaling reduces GABAergic synaptic transmission to gonadotropin-releasing hormone neurons. J Biomol Screen. 151:5818
  PMID: 20926585
• Jones et al. (2010) Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. Br J Pharmacol. 332:569
  PMID: 19906779
• Hao et al. (2010) The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages. J Neurosci. 51:2181
  PMID: 20305287
• Hoffman et al. (2010) Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors. J Neurosci. 30:545
  PMID: 20071517
• Garzón et al. (2009) Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with mor. Mol Pain. 5:11
  PMID: 19284549
• Huerta et al. (2009) Effects of cannabinoids on caffeine contractures in slow and fast skeletal muscle fibers of the frog. J Membr Biol. 229:91
  PMID: 19506935
• Carney et al. (2009) Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells. J Neuroimmune Pharmacol. 4:338
  PMID: 19365734
• McGuinness et al. (2009) Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay. Int J Neuropsychopharmacol. 14:49
  PMID: 19171920
• Ho and Gardiner (2009) Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats. Front Pharmacol. 156:94
  PMID: 19133994
• Price et al. (2009) WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Eur J Neurosci. 29:2177
  PMID: 19490092
• Gibson et al. (2008) TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron. 57:746
  PMID: 18341994
• Kapur et al. (2008) Mapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transduction. J Pharmacol Exp Ther. 325:341
  PMID: 18174385
• Potenzieri et al. (2008) The cannabinoid receptor agonist, WIN 55, 212-2, attenuates tumor-evoked hyperalgesia through peripheral mechanisms. Brain Res. 1215:69
  PMID: 18486111
• Karson et al. (2008) Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others. J Physiol. 54:117
  PMID: 17689570
• Chiu and Castillo (2008) Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology. 54:68
  PMID: 17706254
• Huang et al. (2008) Roles of endocannabinoids in heterosynaptic long-term depression of excitatory synaptic transmission in visual cortex of young mice. J Neurosci. 28:7074
  PMID: 18614676
• Kelm et al. (2008) The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons. J Neurophysiol. 100:3417
  PMID: 18945815
• Kim et al. (2008) Interactions between CB(1) receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic DArgic neurons. Br J Pharmacol. 155:253
  PMID: 18552868
• Huang et al. (2007) Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin/orexin neurons: implications for cannabinoid actions on food intake and cognitive arousal. J Neurosci. 27:4870
  PMID: 17475795
• Pertwee et al. (2007) The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo. Br J Pharmacol. 150:586
  PMID: 17245367
• Marinelli et al. (2007) N-arachidonoyl-DA tunes synaptic transmission onto DArgic neurons by activating both cannabinoid and vanilloid receptors. Neuropsychopharmacology. 32:298
  PMID: 16760924
• Kelm et al. (2007) Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous γ-aminobutyric acid release onto cerebellum Purkinje neurons. J Neurosci. 323:356
  PMID: 17652632
• Narushima et al. (2007) Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. J Neurosci. 27:496
  PMID: 17234582
• Cachope et al. (2007) Potentiation of electrical and chemical synaptic transmission mediated by endocannabinoids. Neuron. 56:1034
  PMID: 18093525
• Hoffman et al. (2007) Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation. Learn Mem. 14:63
  PMID: 17202425
• Akerman et al. (2007) Cannabinoid (CB1) receptor activation inhibits trigeminovascular neurons. J Pharmacol Exp Ther. 320:64
  PMID: 17018694
• Monory et al. (2006) The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron. 51:455
  PMID: 16908411
• Thomas et al. (2005) Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist. Br J Pharmacol. 146:917
  PMID: 16205722
• Hoffman et al. (2005) Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus. J Lipid Res. 22:2387
  PMID: 16262678
• Okada et al. (2005) Biophysical properties of voltage-gated Na+ channels in frog parathyroid cells and their modulation by cannabinoids. J Exp Biol. 208:4747
  PMID: 16326956
• Kettunen et al. (2005) Neuromodulation via conditional release of endocannabinoids in the spinal locomotor network. Neuron. 45:95
  PMID: 15629705
• Haj-Dahmane (2005) The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling. J Neurosci. 25:896
  PMID: 15673670
• Costa et al. (2004) Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain. J Neurosci. 141:42586
  PMID: 14662732
• Galarreta et al. (2004) Electrical coupling among irregular-spiking GABAergic interneurons expressing cannabinoid receptors. J Pharmacol Exp Ther. 24:9770
  PMID: 15525762
• MacNaughton et al. (2004) Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves. Eur J Neurosci. 286:G863
  PMID: 14701723
• Melis et al. (2004) Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in DA neurons. J Neurosci. 24:10707
  PMID: 15564588
• Williams et al. (2003) The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response. EMBO J. 160:481
  PMID: 12578907
• Barann et al. (2002) Direct inhibition by cannabinoids of human 5-HT3A receptors: probable involvement of an allosteric modulatory site. Br J Pharmacol. 137:589
  PMID: 12381672
• McKallip et al. (2002) Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood. 100:627
  PMID: 12091357
• Craib et al. (2001) A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. PLoS One. 134:42581
  PMID: 11522594
• Bridges et al. (2001) The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain. Br J Pharmacol. 133:586
  PMID: 11399676
• Izzo et al. (2000) Modulation of peristalsis by cannabinoid CB(1) ligands in the isolated guinea-pig ileum. Br J Pharmacol. 129:984
  PMID: 10696099
• Izzo et al. (2000) Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oil. Br J Pharmacol. 129:1627
  PMID: 10780967
• Sinnayah et al. Feeding induced by cannabinoids is mediated independently of the melanocortin system. Endocrinology. 3:e2202
  PMID: 18493584
• Michalski et al. Cannabinoids reduce markers of inflammation and fibrosis in pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 3:e1701
  PMID: 18301776

There are no citations that match your criteria.