Key Product Details
Description: | Non-competitive NMDA antagonist; acts at ion channel site |
Alternative Names: | Dizocilpine |
Chemical Name: | (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 337.37 |
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Citations for (+)-MK 801 maleate (91)
Citations are publications that use Bio-Techne products. Selected citations for (+)-MK 801 maleate include:
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Chiu et al.
(2019)
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Cell Rep.
28:332
PMID: 31291571 -
Dubovyk et al.
(2018)
Time-dependent alterations in the expression of NMDA receptor subunits along the dorsoventral hippocampal axis in an animal model of nascent psychosis.
ACS.Chem.Neurosci..
9:2241
PMID: 29634239 -
González-Rueda et al.
(2018)
Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo.
Neuron.
97:1244
PMID: 29503184 -
Sánchez-Blázquez et al.
(2018)
Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice.
Int J Neuropsychopharmacol.
21:938
PMID: 29860313 -
McKay et al.
(2018)
The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences.
Cell Rep.
25:841
PMID: 30355491 -
Lim et al.
(2018)
Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures.
Int J Mol Sci.
19
PMID: 30274399 -
Marinangeli et al.
(2018)
AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation.
iScience.
9:1
PMID: 30368077 -
Kamiya et al.
(2018)
Electrophysiological measurement of ion channels on plasma/organelle membranes using an on-chip lipid bilayer system.
Sci Rep.
8:17498
PMID: 30504856 -
Cai and Ford
(2018)
DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate.
Cell Rep.
25:3148
PMID: 30540946 -
Musella
(2017)
A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum.
Sci Rep.
7(1):7363
PMID: 28779174 -
Brancaccio et al.
(2017)
Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.
Neuron.
93:1420
PMID: 28285822 -
Philippart et al.
(2016)
Differential Somatic Ca2+ Channel Profile in Midbrain DArgic Neurons
The Journal of Neuroscience.
6:7234
PMID: 27383597 -
Freitas et al.
(2016)
Glutathione-Induced Calcium Shifts in Chick Retinal Glial Cells.
PLoS One.
11:e0153677
PMID: 27078878 -
O'Donnell et al.
(2016)
Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
J Neurosci.
36:7109
PMID: 27383588 -
Zou et al.
(2015)
Oligodendrocytes Are Targets of HIV-1 Tat: NMDA and AMPA Receptor-Mediated Effects on Survival and Development.
J Neurosci.
35:11384
PMID: 26269645 -
Rodríguez-Muñoz et al.
(2015)
The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
Int J Neuropsychopharmacol.
6:35458
PMID: 26461475 -
Schitine et al.
(2015)
Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input.
PLoS One.
82:42
PMID: 25700791 -
Chintala et al.
(2015)
Decreased Expression of DREAM Promotes the Degeneration of Retinal Neurons.
Front Aging Neurosci.
10:e0127776
PMID: 26020793 -
Zhang et al.
(2015)
Miro1 deficiency in amyotrophic lateral sclerosis.
Cell Death Dis.
7:100
PMID: 26074815 -
Bertrand et al.
(2015)
Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR.
Cell Death Dis.
6:e1924
PMID: 26469972 -
Birnbaum et al.
(2015)
Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
J Clin Invest.
6:e1791
PMID: 26086964 -
Cipriani et al.
(2015)
FTY720 attenuates excitotoxicity and neuroinflammation.
Curr Mol Med.
12:86
PMID: 25953296 -
Kato et al.
(2015)
Neurobehavioral Differences Between Mice Receiving Distinct Neuregulin Variants as Neonates; Impact on Sensitivity to MK-801.
Cell Death Dis.
15:222
PMID: 25817857 -
Curcio et al.
(2015)
Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
J Neurosci.
6:e1645
PMID: 25675305 -
Stephen et al.
(2015)
Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
Front Behav Neurosci.
35:15996
PMID: 26631479 -
Grüter et al.
(2015)
Altered neuronal excitability underlies impaired hippocampal function in an animal model of psychosis.
J Biol Chem.
9:117
PMID: 26042007 -
Wang et al.
(2015)
MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons.
Nat Commun.
290:168
PMID: 25416777 -
Baxter et al.
(2015)
Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system.
Neuroscience.
6:6761
PMID: 25854456 -
Quillinan et al.
(2015)
Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia.
Neuropharmacology.
284:555
PMID: 25450957 -
Velásquez-Martínez et al.
(2015)
α-1 adrenoreceptors modulate GABA release onto ventral tegmental area DA neurons.
BMC Neurosci.
88:110
PMID: 25261018 -
Owen and Grover
(2015)
Activity-dependent differences in function between proximal and distal Schaffer collaterals.
J Neurophysiol.
113:3646
PMID: 25855695 -
Wang et al.
(2015)
Rewarding Effects of Optical Stimulation of Ventral Tegmental Area Glutamatergic Neurons.
J Neurosci.
35:15948
PMID: 26631475 -
Parnaudeau et al.
(2014)
Glucocorticoid receptor gene inactivation in DA-innervated areas selectively decreases behavioral responses to amphetamine.
Front Behav Neurosci.
8:35
PMID: 24574986 -
Deléglise et al.
(2014)
β-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network.
Acta Neuropathol Commun.
2:145
PMID: 25253021 -
Mirante et al.
(2014)
Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
J Neurosci.
7:62
PMID: 25071439 -
Sánchez-Blázquez et al.
(2014)
The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Neurochem Int.
17:1943
PMID: 24485144 -
Pan et al.
(2014)
Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits.
J Neuroinflammation.
124:4629
PMID: 25202982 -
Lundgaard et al.
(2013)
Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
PLoS Biol.
11:e1001743
PMID: 24391468 -
Vicente-Sánchez et al.
(2013)
HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
Mol Brain.
6:42
PMID: 24093505 -
Tamburri et al.
(2013)
NMDA-receptor activation but not ion flux is required for amyloid-β induced synaptic depression.
PLoS One.
8:e65350
PMID: 23750255 -
Tsunekawa et al.
(2013)
Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation.
J Neuroinflammation.
14:4
PMID: 23289926 -
Pasquale and Sherman
(2013)
A modulatory effect of the feedback from higher visual areas to V1 in the mouse.
J Neurophysiol.
109:2618
PMID: 23446698 -
Naka et al.
(2013)
Non-Hebbian plasticity at C-fiber synapses in rat spinal cord lamina I neurons.
Pain.
154:1333
PMID: 23707311 -
Koeglsperger et al.
(2013)
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
Glia.
61:985
PMID: 23536313 -
Bengtson et al.
(2013)
Calcium responses to synaptically activated bursts of action potentials and their synapse-independent replay in cultured networks of hippocampal neurons.
Biochim Biophys Acta.
1833:1672
PMID: 23360982 -
Rojas et al.
(2013)
Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
Mol Pharmacol.
83:106
PMID: 23066089 -
Rodríguez-Muñoz et al.
(2012)
The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.
Neuropsychopharmacology.
37:338
PMID: 21814188 -
Lee and Sherman
(2012)
Intrinsic modulators of auditory thalamocortical transmission.
Hear Res.
287:43
PMID: 22726616 -
Cassé et al.
(2012)
Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
J Neurosci.
32:5186
PMID: 22496564 -
Gaamouch et al.
(2012)
Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
J Neurosci.
32:10767
PMID: 22855824 -
Kocsis
(2012)
State-dependent increase of cortical gamma activity during REM sleep after selective blockade of NR2B subunit containing NMDA receptors.
Sleep.
35:1011
PMID: 22754048 -
Pedrazzi et al.
(2012)
Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein.
PLoS One.
7:e44518
PMID: 22952988 -
Kaufman et al.
(2012)
Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
FASEB J.
32:3992
PMID: 22442066 -
Jarzylo and Man
(2012)
Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability.
J Neurosci.
32:2552
PMID: 22396428 -
Laricchiuta et al.
(2012)
Differences in spontaneously avoiding or approaching mice reflect differences in CB1-mediated signaling of dorsal striatal transmission.
PLoS One.
7:e33260
PMID: 22413007 -
Rossi et al.
(2012)
Interleukin-1β causes anxiety by interacting with the endocannabinoid system.
J Neurosci.
32:13896
PMID: 23035099 -
Blouet and Schwartz
(2012)
Duodenal lipid sensing activates vagal afferents to regulate non-shivering brown fat thermogenesis in rats.
PLoS One.
7:e51898
PMID: 23251649 -
Carlson et al.
(2012)
Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
Brain Behav.
2:391
PMID: 22950043 -
Peterfi et al.
(2012)
Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.
J Neurosci.
32:14448
PMID: 23055515 -
Kim et al.
(2012)
Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1.
J Neurophysiol.
108:1965
PMID: 22773781 -
Klug et al.
(2012)
Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.
PLoS One.
7:e45323
PMID: 23028932 -
Straub et al.
(2011)
Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
Nat Neurosci.
14:866
PMID: 21623363 -
Lecrux et al.
(2011)
Pyramidal neurons are "neurogenic hubs" in the neurovascular coupling response to whisker stimulation.
J Neurosci.
31:9836
PMID: 21734275 -
Roselli et al.
(2011)
CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
PLoS One.
6:e23097
PMID: 21829588 -
Léveillé et al.
(2010)
Suppression of the intrinsic apoptosis pathway by synaptic activity.
J Neurosci.
30:2623
PMID: 20164347 -
Chang et al.
(2010)
Rapid activation of dormant presynaptic terminals by phorbol esters.
J Neurosci.
30:10048
PMID: 20668189 -
Talpalar and Kiehn
(2010)
Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG.
Front Neural Circuits.
4
PMID: 20844601 -
Chao et al.
(2009)
Na+ mechanism of delta-opioid receptor induced protection from anoxic K+ leakage in the cortex.
Cell Mol Life Sci.
66:1105
PMID: 19189047 -
Roselli et al.
(2009)
Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
PLoS One.
4:e6011
PMID: 19547699 -
Gielen et al.
(2009)
Mechanism of differential control of NMDA receptor activity by NR2 subunits.
J Cereb Blood Flow Metab.
459:703
PMID: 19404260 -
Fallarini et al.
(2009)
Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death.
Br J Pharmacol.
157:1072
PMID: 19466982 -
Léveillé et al.
(2008)
Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
FASEB J.
22:4258
PMID: 18711223 -
Furness et al.
(2008)
A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2).
Neuroscience.
157:80
PMID: 18805467 -
Pais et al.
(2008)
Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway.
J Neurosci.
5:43
PMID: 18844999 -
Iwasato et al.
(2008)
Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
J Neurosci.
28:5931
PMID: 18524897 -
Albright et al.
(2007)
Increased thalamocortical synaptic response and decreased layer IV innervation in GAP-43 knockout mice.
J Neurophysiol.
98:1610
PMID: 17581849 -
Steward et al.
(2007)
A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction.
Learn Mem.
14:433
PMID: 17562895 -
Brager and Johnston
(2007)
Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons.
J Neurosci.
27:13926
PMID: 18094230 -
Joo et al.
(2007)
Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells.
J Cell Sci.
120:1358
PMID: 17389682 -
Chen et al.
(2007)
PREGS induces LTP in the hippocampal dentate gyrus of adult rats via the tyrosine phosphorylation of NR2B coupled to ERK/CREB [corrected] signaling.
J Neurophysiol.
98:1538
PMID: 17625058 -
Shin et al.
(2006)
Vasoconstrictive neurovascular coupling during focal ischemic depolarizations.
J Cereb Blood Flow Metab.
26:1018
PMID: 16340958 -
Calò et al.
(2005)
Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons.
J Neurosci.
25:2245
PMID: 15745950 -
Shleper et al.
(2005)
D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices.
Nature.
25:9413
PMID: 16221850 -
Gerstner et al.
(2005)
Glutaric acid and its metabolites cause apoptosis in immature oligodendrocytes: a novel mechanism of white matter degeneration in glutaryl-CoA dehydrogenase deficiency.
Pediatr Res.
57:771
PMID: 15774829 -
Tongiorgi et al.
(2004)
Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis.
J Neurosci.
24:6842
PMID: 15282290 -
Liot et al.
(2004)
2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one dihydrochloride, tPA stop, prevents tPA-enhanced excitotoxicity both in vitro and in vivo.
Proc Natl Acad Sci U S A.
24:1153
PMID: 15529015 -
Gabriel et al.
(2003)
Transforming growth factor alpha-induced expression of type 1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity.
FASEB J.
17:277
PMID: 12490542 -
Valable et al.
(2003)
Angiopoietin-1-induced PI3-kinase activation prevents neuronal apoptosis.
Oncotarget.
17:443
PMID: 12514118 -
Chen et al.
(2002)
Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa
J Virol.
76:9407
PMID: 12186923 -
Rzeski et al.
(2001)
Glutamate antagonists limit tumor growth.
J Neurosci.
98:6372
PMID: 11331750 -
Matthies et al.
(2000)
Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampus.
Learn Mem.
7:227
PMID: 10940323
There are no citations that match your criteria.
Customer Reviews for (+)-MK 801 maleate (1)
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Species: RatAssay Type: In VitroCell Line/Tissue: Sprague-Dawley rats primary neuronal10 μM MK-801 for 10 min
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