(+)-MK 801 maleate

Product Description

(+)-MK 801 maleate is a high affinity (K_i = 37.2 nM), selective and non-competitive NMDA receptor antagonist. (+)-MK 801 maleate acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca²⁺ flux. It is an effective anti-ischemic agent in several animal models. (+)-MK 801 maleate increases motor activity in rat models. (+)-MK 801 maleate inhibits proliferation and increases apoptosis in hippocampal neural stem cells (NSCs). (+)-MK 801 maleate induces schizophrenia-like symptoms in rodents.

(-)-enantiomer also available.

Solubility

Preparing Stock Solutions for (+)-MK 801 maleate

The following data is based on the product molecular weight 337.37

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.82 mL	29.64 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ding Effect of NMDA on proliferation and apoptosis in hippocampal neural stem cells treated with MK-801. Exp.Ther.Med. 2018 PMID: 30116364
• Carey Effects of dizocilpine (MK-801) on motor activity and memory. Psychopharmacology 1998 PMID: 9683001
• Zajaczkowski Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology 1997 PMID: 9257940
• Wong The anticonvulsant MK 801 is a potent N-MthD.-aspartate antagonist. Proc.Natl.Acad.Sci.U.S.A. 1986 PMID: 3529096
• Hatfield The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model. Eur.J.Pharmacol. 1992 PMID: 1526248
• Gill The neuroprotective action of dizocilpine (MK-801) in the rat middle cerebral artery occlusion model of focal ischaemia. Br.J.Pharmacol. 1991 PMID: 1912992