(-)-MK 801 maleate
Tocris Bioscience, part of Bio-Techne | Catalog # 0955
NMDA antagonist; less active enantiomer of (+)-MK 801
Key Product Details
Description
NMDA antagonist; less active enantiomer of (+)-MK 801
Product Description
(-)-MK 801 maleate is a less active enantiomer (10-fold less potent in behavioral studies) than (+)-MK 801 maleate.(+)-enantiomer also available.
Product Specifications
Molecular Weight
337.37
Formula
C16H15N.C4H4O4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(5R,10S)-(-)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cylcohepten-5,10-imine maleate
CAS Number
121917-57-5
PubChem ID
16219612
InChI Key
QLTXKCWMEZIHBJ-FWHYOZOBSA-N
SMILES
O=C(O)/C=C\C(O)=O.C[C@@]14C3=C(C=CC=C3)C[C@H](N4)C2=C1C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.43 | 25 with gentle warming | |
| DMSO | 33.74 | 100 |
Preparing Stock Solutions
for (-)-MK 801 maleate
The following data is based on the product molecular weight 337.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.82 mL | 29.64 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.93 mL |
| 10 mM | 0.30 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thompson Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-MthD.-aspartate antagonists. J.Med.Chem. 1990 PMID: 1688947
- Genovese and Lu Effects of MK-801 stereoisomers on schedule-controlled behavior in rats. Psychopharmacology. 1991 PMID: 1771215
Product Specific Notices for (-)-MK 801 maleate
For research use only
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