(-)-MK 801 maleate

Name: (-)-MK 801 maleate
Brand: tocris
SKU: 0955

Catalog # 0955

Citations (3)

Datasheet / COA / SDS

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Key Product Details

Description:	NMDA antagonist; less active enantiomer of (+)-MK 801
Chemical Name:	(5R,10S)-(-)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cylcohepten-5,10-imine maleate
Purity:	≥99% (HPLC)
Molecular Weight:	337.37

View Full Technical Details for (-)-MK 801 maleate

Biological Activity

(-)-MK 801 maleate is a less active enantiomer (10-fold less potent in behavioral studies) than (+)-MK 801 maleate.

(+)-enantiomer also available.

Compound Libraries

(-)-MK 801 maleate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	337.37
Formula	C₁₆H₁₅N.C₄H₄O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	121917-57-5
PubChem ID	16219612
InChi Key	QLTXKCWMEZIHBJ-FWHYOZOBSA-N
Smiles	O=C(O)/C=C\C(O)=O.C[C@@]14C3=C(C=CC=C3)C[C@H](N4)C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	8.43	25 with gentle warming
	DMSO	33.74	100

Preparing Stock Solutions

The following data is based on the product molecular weight 337.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.82 mL	29.64 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References

References are publications that support the biological activity of the product.

Genovese and Lu Effects of MK-801 stereoisomers on schedule-controlled behavior in rats. Psychopharmacology. 1991 PMID: 1771215
Thompson Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-MthD.-aspartate antagonists. J.Med.Chem. 1990 PMID: 1688947

Citations (3)

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Citations are publications that use Bio-Techne products. Selected citations for (-)-MK 801 maleate include:

Huang et al. (2007) Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendrites. J Neurosci. 27:9054
PMID: 17715342
Yang et al. (2005) Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Pharmacol Exp Ther. 25:4288
PMID: 15858055
Huang et al. (2004) Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci. 24:4551
PMID: 15140926

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Product Documents

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

(-)-MK 801 maleate

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Key Product Details

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References

Citations (3)

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COA

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