Pirfenidone

Name: Pirfenidone
Brand: Tocris Bioscience
SKU: 1093

Catalog # 1093

Citations (1)

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Key Product Details

Description:	Antifibrotic agent; regulates cytokine levels in vivo
Chemical Name:	5-methyl-1-phenyl-2(1H)-pyridinone
Purity:	≥99% (HPLC)
Molecular Weight:	185.23

View Full Technical Details for Pirfenidone

Biological Activity

Pirfenidone is a antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.

Technical Data

M. Wt	185.23
Formula	C₁₂H₁₁NO
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	53179-13-8
PubChem ID	40632
InChi Key	ISWRGOKTTBVCFA-UHFFFAOYSA-N
Smiles	CC1=CN(C(=O)C=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	3.7	20

Preparing Stock Solutions

The following data is based on the product molecular weight 185.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	26.99 mL	134.97 mL	269.93 mL
1 mM	5.40 mL	26.99 mL	53.99 mL
2 mM	2.70 mL	13.50 mL	26.99 mL
10 mM	0.54 mL	2.70 mL	5.40 mL

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References

References are publications that support the biological activity of the product.

Mei Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats. J.Pharmacol.Exp.Ther. 2005 PMID: 15608079
Oku Pirfenidone suppresses tumor necrosis factor-α, enhances interleukin-10 and protects mice from endotoxic shock. Eur.J.Pharmacol. 2002 PMID: 12098599
Iyer Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleo. hamster model of lung fibrosis. J.Pharmacol.Exp.Ther. 1999 PMID: 10087006
Kehrer and Margolin Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice. Toxicol.Lett. 1997 PMID: 9067480

Citations for Pirfenidone (1)

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Citations are publications that use Bio-Techne products. Selected citations for Pirfenidone include:

Griffiths (2018) Anti-fibrotic effects of CXCR4-targeting i-body AD-114 in preclinical models of pulmonary fibrosis. Sci Rep. 8(1):3212
PMID: 29453386

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