Phenamil
Tocris Bioscience, part of Bio-Techne | Catalog # 3379
Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channels
Key Product Details
Description
Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channels
Product Description
Phenamil is a TRPP3 channel inhibitor (IC50 = 0.14 μM). Also inhibits epithelial Na+ channels (Kd = 0.4 nM for a high affinity site on the epithelial Na+ channel). Derivative of amiloride (Cat. No. 0890).Product Specifications
Molecular Weight
401.83
Formula
C12H12ClN7O.CH3SO3H
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt
CAS Number
1161-94-0
PubChem ID
9604979
InChI Key
MHPIZTURFVSLTJ-UHFFFAOYSA-N
SMILES
NC1=C(Cl)N=C(C(NC(NC2=CC=CC=C2)=N)=O)C(N)=N1.CS(=O)(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.18 | 100 |
Preparing Stock Solutions
for Phenamil
The following data is based on the product molecular weight 401.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.49 mL | 12.44 mL | 24.89 mL |
| 5 mM | 0.50 mL | 2.49 mL | 4.98 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.49 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dai Inhibition of TRPP3 channel by amil. and analogs. Mol.Pharmacol. 2007 PMID: 17804601
- Barbry Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive Na+ channels. Biochemistry. 1989 PMID: 2546581
Product Specific Notices for Phenamil
For research use only
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