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Amiloride hydrochloride

Voltage-gated Sodium Channel Blockers Small Molecule

Key Product Details

Description: Na+ channel blocker; also I2 imidazoline ligand
Chemical Name: 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride
Purity: ≥98% (HPLC)

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Citations (7)

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  • Drug treatments
    Name: Andrew Poon | 1st Mar 2019
    Species: Other
    Assay Type: In Vitro
    Amiloride was combined with chemotherapy to assess its potential to kill canine osteosarcoma cells, and was found to be synergistic with doxorubicin chemotherapy. It was also used by the Seahorse analyzer to show that the extracellular acidification rate (ECAR) decreases after amiloride exposure.
    Dissolve the powder in 100 mM DMSO, and dilute according to minimize vehicle effects.
    Drug treatments Serum 0890
  • ASIC inhibition on acute brain slices
    Name: Anonymous | 10th Jan 2018
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: acute brain slice
    Used to show ASIC channels were not involved in the studied effect. No effect was had, as expected, however it's hard to control for the drug efficacy as we did not show ASIC blockade directly.

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