Amiloride hydrochloride
Catalog # 0890 | Tocris Bioscience a Bio-Techne Brand
Na+ channel blocker; also I2 imidazoline ligand
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Key Product Details
Description: | Na+ channel blocker; also I2 imidazoline ligand |
Chemical Name: | 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 266.09 |
Citations for Amiloride hydrochloride (7)
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Citations are publications that use Bio-Techne products. Selected citations for Amiloride hydrochloride include:
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Neubert et al.
(2020)
NCX1 Represents an Ionic Na+ Sensing Mechanism in Macrophages
PloS Biol.
18
PMID: 32569301 -
Roebber et al.
(2019)
The Role of the Anion in Salt (NaCl) Detection by Mouse Taste Buds.
J Neurosci.
39:6224
PMID: 31171579 -
Messerschmidt et al.
(2019)
Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation.
Mol Vis.
25:329
PMID: 31341381 -
Poon et al.
(2018)
Effects of the potassium-sparing diuretic amil. on chemotherapy response in canine osteosarcoma cells.
J Vet Intern Med.
33:800
PMID: 30556178 -
Barbaro
(2017)
Dendritic cell amiloride-sensitive channels mediate sodium-induced inflammation and hypertension.
Cell Rep.
21(4):1009
PMID: 29069584 -
Korang-Yeboah et al.
(2015)
Polycaprolactone/maltodextrin nanocarrier for intracellular drug delivery: formulation, uptake mechanism, internalization kinetics, and subcellular localization.
J Neurosci.
10:4763
PMID: 26251597 -
Jeong et al.
(2013)
Antinociceptive effects of amil. and benzamil in neuropathic pain model rats.
Int J Nanomedicine.
28:1238
PMID: 23960454
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Customer Reviews for Amiloride hydrochloride (2)
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Species: OtherAssay Type: In VitroAmiloride was combined with chemotherapy to assess its potential to kill canine osteosarcoma cells, and was found to be synergistic with doxorubicin chemotherapy. It was also used by the Seahorse analyzer to show that the extracellular acidification rate (ECAR) decreases after amiloride exposure.Dissolve the powder in 100 mM DMSO, and dilute according to minimize vehicle effects.
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Species: MouseAssay Type: In VivoCell Line/Tissue: acute brain sliceUsed to show ASIC channels were not involved in the studied effect. No effect was had, as expected, however it's hard to control for the drug efficacy as we did not show ASIC blockade directly.
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