pCPA methyl ester hydrochloride

Name: pCPA methyl ester hydrochloride
Brand: Tocris Bioscience
SKU: 5871

Tocris Bioscience, part of Bio-Techne | Catalog # 5871

Citations (4)

COA / SDS

Tryptophan hydroxylase inhibitor

Key Product Details

Description:	Tryptophan hydroxylase inhibitor
Chemical Name:	4-Chloro-DL-Phenylalanine methyl ester hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	250.12

View Full Technical Details for pCPA methyl ester hydrochloride

Technical Data
Citations

Biological Activity for pCPA methyl ester hydrochloride

pCPA methyl ester hydrochloride is a tryptophan hydroxylase inhibitor. Inhibits 5-HT synthesis. Depletes 5-HT levels in orbitofrontal cortex and impairs reversal learning in rats. Methyl ester of p-Chlorophenylalanine (Cat. No. 0938).

Compound Libraries for pCPA methyl ester hydrochloride

pCPA methyl ester hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for pCPA methyl ester hydrochloride

M. Wt	250.12
Formula	C₁₀H₁₂ClNO₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	14173-40-1
PubChem ID	26531
InChi Key	GCBCWTWQAFLKJG-UHFFFAOYSA-N
Smiles	O=C(C(CC1=CC=C(C=C1)Cl)N)OC.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for pCPA methyl ester hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	25.01	100
	DMSO	25.01	100

Preparing Stock Solutions for pCPA methyl ester hydrochloride

The following data is based on the product molecular weight 250.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.00 mL	19.99 mL	39.98 mL
5 mM	0.80 mL	4.00 mL	8.00 mL
10 mM	0.40 mL	2.00 mL	4.00 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

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Reconstitution Calculator

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References for pCPA methyl ester hydrochloride

References are publications that support the biological activity of the product.

Wallace Vort. restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. Int.J.Neuropsychopharmacol. 2014 PMID: 24852131
Pinto Brod Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test. Prog.Neuropsychopharmacol.Biol.Psychiatry. 2016 PMID: 26596986