p-Chlorophenylalanine

Name: p -Chlorophenylalanine
Brand: Tocris Bioscience
SKU: 0938

Tocris Bioscience a Bio-Techne Brand

Catalog # 0938

Citations (2)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Tryptophan hydroxylase inhibitor
Purity:	≥99% (HPLC)
Molecular Weight:	199.64

View Full Technical Details for p-Chlorophenylalanine

Complete Your Research

7-Ethoxyresorufin

Cat # 6204

CP 809101 hydrochloride

Cat # 3041

Citations (5)

JZL 195

Cat # 4715

LY 379268

Cat # 2453

Citations (19)

CGP 12177 hydrochloride

Cat # 1134

Citations (6)

IPA 3

Cat # 3622

Citations (21)

Antibiotic; inhibits bacterial DNA synthesis

Viomycin

Cat # 3787

(1)

Citations (4)

TCS 2312

Cat # 3038

Citations (2)

Indoleamine 2,3-dioxygenase (IDO) inhibitor

1-Methyl-D-tryptophan

Cat # 5698

SB 297006

Cat # 4213

Beraprost sodium

Cat # 4180

Sulprostone

Cat # 3049

Citations (1)

Inhibits TRPP3-mediated currents; also inhibits epithelial Na+ channels

Phenamil

Cat # 3379

Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker

Fendiline Hydrochloride

Cat # 6407

Potent and selective non-peptide AT2 antagonist

PD 123319 ditrifluoroacetate

Cat # 1361

(1)

Citations (22)

JNJ 5207852 dihydrochloride

Cat # 4020

ATP citrate lyase inhibitor; orally bioavailable

BMS 303141

Cat # 4609

Citations (3)

Technical Data
Citations (2) / Reviews

Biological Activity for p-Chlorophenylalanine

p-Chlorophenylalanine is a binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain.

Technical Data for p-Chlorophenylalanine

M. Wt	199.64
Formula	C₉H₁₀ClNO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	7424-00-2
PubChem ID	4652
InChi Key	NIGWMJHCCYYCSF-UHFFFAOYSA-N
Smiles	NC(C(O)=O)CC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for p-Chlorophenylalanine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		10

Preparing Stock Solutions for p-Chlorophenylalanine

The following data is based on the product molecular weight 199.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	50.09 mL	250.45 mL	500.90 mL
0.5 mM	10.02 mL	50.09 mL	100.18 mL
1 mM	5.01 mL	25.05 mL	50.09 mL
5 mM	1.00 mL	5.01 mL	10.02 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for p-Chlorophenylalanine

References are publications that support the biological activity of the product.

Datla and Curzon Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats. Neuropharmacology 1996 PMID: 8783206
Koyuncuoglu The effects of DL-p-chlorophenylalanine and DL-α-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat. Psychopharmacologia 1975 PMID: 129787

Citations for p-Chlorophenylalanine (2)

Showing 1 - 2 of 2 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for p-Chlorophenylalanine include:

Tullius et al. (2014) NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Nat Commun. 5:5101
PMID: 25290058
Hernandez et al. (2012) Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Proc Natl Acad Sci U S A. 302:E1009
PMID: 22318950

There are no citations that match your criteria.