p-Chlorophenylalanine

Name: p -Chlorophenylalanine
Brand: tocris
SKU: 0938

Catalog # 0938

Citations (2)

Datasheet / COA / SDS

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Key Product Details

Description:	Tryptophan hydroxylase inhibitor
Purity:	≥99% (HPLC)
Molecular Weight:	199.64

View Full Technical Details for p-Chlorophenylalanine

Biological Activity

p-Chlorophenylalanine is a binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain.

Technical Data

M. Wt	199.64
Formula	C₉H₁₀ClNO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	7424-00-2
PubChem ID	4652
InChi Key	NIGWMJHCCYYCSF-UHFFFAOYSA-N
Smiles	NC(C(O)=O)CC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		10

Preparing Stock Solutions

The following data is based on the product molecular weight 199.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	50.09 mL	250.45 mL	500.90 mL
0.5 mM	10.02 mL	50.09 mL	100.18 mL
1 mM	5.01 mL	25.05 mL	50.09 mL
5 mM	1.00 mL	5.01 mL	10.02 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Datla and Curzon Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats. Neuropharmacology 1996 PMID: 8783206
Koyuncuoglu The effects of DL-p-chlorophenylalanine and DL-α-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat. Psychopharmacologia 1975 PMID: 129787

Citations (2)

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Citations are publications that use Bio-Techne products. Selected citations for p-Chlorophenylalanine include:

Tullius et al. (2014) NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Nat Commun. 5:5101
PMID: 25290058
Hernandez et al. (2012) Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Proc Natl Acad Sci U S A. 302:E1009
PMID: 22318950

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Product Documents

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

p-Chlorophenylalanine

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Key Product Details

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Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (2)

Product Documents

COA

Certificate of Analysis

SDS

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