OUL 35

Name: OUL 35
Brand: Tocris Bioscience
SKU: 6344

Tocris Bioscience a Bio-Techne Brand

Catalog # 6344

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Key Product Details

Description:	Selective PARP-10 inhibitor
Chemical Name:	4,4'-Oxybis[benzamide]
Purity:	≥98% (HPLC)
Molecular Weight:	256.26

View Full Technical Details for OUL 35

Biological Activity for OUL 35

OUL 35 is a selective PARP-10 (also known as ADP-ribosyltransferase Diptheria Toxin-like 10, ARTD10) inhibitor (IC₅₀ = 0.329 μM). Displays selectivity for PARP-10 over a panel of PARP family members. Rescues HeLa cells from PARP-10-induced cell death. Sensitizes cancer cells to hydroxyurea-induced genotoxic stress.

Compound Libraries for OUL 35

OUL 35 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for OUL 35

M. Wt	256.26
Formula	C₁₄H₁₂N₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	6336-34-1
PubChem ID	236501
InChi Key	XZRCQWLPMXFGHE-UHFFFAOYSA-N
Smiles	NC(C1=CC=C(C=C1)OC2=CC=C(C(N)=O)C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OUL 35

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.63	100

Preparing Stock Solutions for OUL 35

The following data is based on the product molecular weight 256.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.90 mL	19.51 mL	39.02 mL
5 mM	0.78 mL	3.90 mL	7.80 mL
10 mM	0.39 mL	1.95 mL	3.90 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

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Reconstitution Calculator

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References for OUL 35

References are publications that support the biological activity of the product.

Venkannagari Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage. Cell Chem.Biol. 2016 PMID: 27667561

Citations for OUL 35

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