OUL 35
Tocris Bioscience, part of Bio-Techne | Catalog # 6344
Selective PARP-10 inhibitor
Key Product Details
Description
Selective PARP-10 inhibitor
Product Description
OUL 35 is a selective PARP-10 (also known as ADP-ribosyltransferase Diptheria Toxin-like 10, ARTD10) inhibitor (IC50 = 0.329 μM). Displays selectivity for PARP-10 over a panel of PARP family members. Rescues HeLa cells from PARP-10-induced cell death. Sensitizes cancer cells to hydroxyurea-induced genotoxic stress.Product Specifications
Molecular Weight
256.26
Formula
C14H12N2O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4,4'-Oxybis[benzamide]
CAS Number
6336-34-1
PubChem ID
236501
InChI Key
XZRCQWLPMXFGHE-UHFFFAOYSA-N
SMILES
NC(C1=CC=C(C=C1)OC2=CC=C(C(N)=O)C=C2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.63 | 100 |
Preparing Stock Solutions
for OUL 35
The following data is based on the product molecular weight 256.26
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.90 mL | 19.51 mL | 39.02 mL |
| 5 mM | 0.78 mL | 3.90 mL | 7.80 mL |
| 10 mM | 0.39 mL | 1.95 mL | 3.90 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Venkannagari Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage. Cell Chem.Biol. 2016 PMID: 27667561
Product Specific Notices for OUL 35
For research use only
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