ω-Conotoxin GVIA

Name: ω-Conotoxin GVIA
Brand: Tocris Bioscience
SKU: 1085
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1085

(3)

Citations (23)

COA / SDS

CaV2.2 blocker

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Technical Data
Citations & Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

CaV2.2 blocker

View all Cav2.x Channel Blockers »

Product Description

ω-Conotoxin GVIA is a peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC₅₀ = 0.15 nM). Reduces (RS)-3,5-DHPG (Cat. No. 0342)-induced long term depression in vivo.

Product Specifications

Molecular Weight

3037.00

Formula

C₁₂₀H₁₈₂N₃₈O₄₃S₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

106375-28-4

PubChem ID

90479753

InChI Key

DRVGOMCWRXUORL-QPEMYEDGSA-N

SMILES

[H]N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)C4C(O)CCN4C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)C4C(O)CCN4C(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](CO)C(=O)N1CCC(O)C1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N3)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Sato Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels. Biochem.Biophys.Res.Comm. 1993 PMID: 8394704
Wright and Angu Prolonged cardiovascular effects of the N-type Ca²⁺ channel antagonist ω-conotoxin GVIA in conscious rabbits. J.Cardiovasc.Pharmacol. 1997 PMID: 9300325
Connelly Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression. Eur.J.Pharmacol. 2011 PMID: 21575629
Tsien Multiple types of neuronal calcium channels and their selective modulation. TiNS 1988 PMID: 2469160