Olopatadine hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4241

H1 antagonist; ocular antiallergic agent
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Key Product Details

Description

H1 antagonist; ocular antiallergic agent

View all Histamine H1 Receptor Antagonists »

Product Description

Olopatadine hydrochloride is a histamine H1 receptor antagonist (Ki = 31.6 nM). Inhibits the release of histamine, prostaglandin D2 and tryptase in a concentration-dependent manner. Mast cell stabilizer; inhibits mast cell mediator release. Also suppresses inflammation by inhibition of cytokine production.

Product Specifications

Molecular Weight

373.87

Formula

C21H23NO3.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride

CAS Number

140462-76-6

PubChem ID

5282402

InChI Key

HVRLZEKDTUEKQH-NOILCQHBSA-N

SMILES

O=C(CC(C=C3)=CC/1=C3OCC(C=CC=C2)=C2C1=C\CCN(C)C)O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 28.04 75
DMSO 37.39 100

Preparing Stock Solutions for Olopatadine hydrochloride

The following data is based on the product molecular weight 373.87

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.37 mL 26.75 mL
5 mM 0.53 mL 2.67 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Olopatadine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Olopatadine hydrochloride

For research use only

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