Olaparib

Name: Olaparib
Brand: Tocris Bioscience
SKU: 7579
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 7579

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Key Product Details

Description:	Potent PARP inhibitor
Chemical Name:	4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone
Purity:	≥98% (HPLC)
Molecular Weight:	434.47

View Full Technical Details for Olaparib

Biological Activity for Olaparib

Olaparib is a potent PARP2 and PARP1 inhibitor (IC₅₀ values are 1 and 5 nM, respectively). Olaparib abolishes PARP-1 activity at a concentration of 30-100 nM in SW620 cell lysates. BRCA1-deficient cell lines are hypersensitive to PARP inhibition by Olaparib in comparison with BRCA1- and BRCA2-proficient cells. Olaparib potentiates the antitumor activity of the methylating chemotherapeutic agent Temozolomide (Cat. No. 2706) in xenograft mouse model. Olaparib is orally bioavailable in rats.

Technical Data for Olaparib

M. Wt	434.47
Formula	C₂₄H₂₃FN₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	763113-22-0
PubChem ID	23725625
InChi Key	FDLYAMZZIXQODN-UHFFFAOYSA-N
Smiles	O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CCN(C(=O)C5CC5)CC4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Olaparib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	2.17	5 with gentle warming
	DMSO	43.45	100

Preparing Stock Solutions for Olaparib

The following data is based on the product molecular weight 434.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.51 mL	23.02 mL
5 mM	0.46 mL	2.30 mL	4.60 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for Olaparib

References are publications that support the biological activity of the product.

Raimundo BBIT20 inhibits homologous DNA repair with disruption of the BRCA1-BARD1 interaction in breast and ovarian cancer. Br.J.Pharmacol. 2021 PMID: 33899955
Menear 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J.Med.Chem. 2008 PMID: 18800822

Citations for Olaparib

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PARP inhibitor

Name: Kishor Pant

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: RBE and HepG2

It's an excellent selective inhibitor of PARP. This drug induces DNA damage in cancer cells. Used at 1-10 uM.

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