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NPS 2390

Bio-Techne includes Tocris Bioscience | Catalog # 4134

Group I mGlu antagonist
Group I mGlu antagonist

Key Product Details

Description: Group I mGlu antagonist
Chemical Name: N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide
Purity: ≥99% (HPLC)
Molecular Weight: 307.39

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  • Use of NPS 2390 to isolate GABA-A receptor response
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Cerebellum
    NPS 2390 was used as a specific blocker of mGluR1 and mGluR5, to isolate pharmacologically response of GABA-A receptors. 10 microM of NPS 2390 in perfusion solution generated a full block of mGluR group I receptor activity, thus leaving a clear GABA-ergic response. Figure: single-channel openings of GABA-A receptor after application of NPS 2390.
    Compound requires sonication to be dissolved.
    NPS 2390 Serum 4134

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Product Documents for NPS 2390

Certificate of Analysis

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