NPS 2390

Name: NPS 2390
Brand: Tocris Bioscience
SKU: 4134
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4134

Citations (2)

(1)

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Key Product Details

Description:	Group I mGlu antagonist
Chemical Name:	N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	307.39

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Biological Activity for NPS 2390

NPS 2390 is a group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu₁ and mGlu₅ receptors. Thought to act on a site separate from the glutamate binding pocket.

Compound Libraries for NPS 2390

NPS 2390 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NPS 2390

M. Wt	307.39
Formula	C₁₉H₂₁N₃O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	226878-01-9
PubChem ID	7067728
InChi Key	ZKFVOZCCAXQXBU-UHFFFAOYSA-N
Smiles	O=C(C4=NC(C=CC=C5)=C5N=C4)NC1(CC3C2)CC(C3)CC2C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NPS 2390

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	15.37	50
	ethanol	15.37	50

Preparing Stock Solutions for NPS 2390

The following data is based on the product molecular weight 307.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.51 mL	32.53 mL	65.06 mL
2.5 mM	1.30 mL	6.51 mL	13.01 mL
5 mM	0.65 mL	3.25 mL	6.51 mL
25 mM	0.13 mL	0.65 mL	1.30 mL

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References for NPS 2390

References are publications that support the biological activity of the product.

Mabire Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists. J.Med.Chem. 2005 PMID: 15771457
Lavreysen [³H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol.Pharmacol. 2003 PMID: 12695537
van Wagenen Structure-activity relationship studies of NPS 2390: a potent and selective group I metabotropic glutamate receptor antagonist. Abstr.Soc.Neurosci.

Citations for NPS 2390 (2)

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Citations are publications that use Bio-Techne products. Selected citations for NPS 2390 include:

Lezmy et al. (2021) Astrocyte Ca ²⁺-evoked ATP release regulates myelinated axon excitability and conduction speed. Science. 374:eabh2858
PMID: 34648330
Li et al. (2016) Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor. Oxid Med Cell Longev. 2016:5203801
PMID: 27965733

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Use of NPS 2390 to isolate GABA-A receptor response

Name: Anonymous

Species: Rat

Assay Type: In Vitro

Cell Line/Tissue: Cerebellum

NPS 2390 was used as a specific blocker of mGluR1 and mGluR5, to isolate pharmacologically response of GABA-A receptors. 10 microM of NPS 2390 in perfusion solution generated a full block of mGluR group I receptor activity, thus leaving a clear GABA-ergic response. Figure: single-channel openings of GABA-A receptor after application of NPS 2390.

Compound requires sonication to be dissolved.

PMID: 30042389

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Product Documents for NPS 2390

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.