NPS 2390
Tocris Bioscience, part of Bio-Techne | Catalog # 4134
Group I mGlu antagonist
Product Description
NPS 2390 is a group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. Thought to act on a site separate from the glutamate binding pocket.Product Specifications
Molecular Weight
307.39
Formula
C19H21N3O
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide
CAS Number
226878-01-9
PubChem ID
7067728
InChI Key
ZKFVOZCCAXQXBU-UHFFFAOYSA-N
SMILES
O=C(C4=NC(C=CC=C5)=C5N=C4)NC1(CC3C2)CC(C3)CC2C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.37 | 50 | |
| Ethanol | 15.37 | 50 |
Preparing Stock Solutions
for NPS 2390
The following data is based on the product molecular weight 307.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.51 mL | 32.53 mL | 65.06 mL |
| 2.5 mM | 1.30 mL | 6.51 mL | 13.01 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
| 25 mM | 0.13 mL | 0.65 mL | 1.30 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mabire Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists. J.Med.Chem. 2005 PMID: 15771457
- van Wagenen Structure-activity relationship studies of NPS 2390: a potent and selective group I metabotropic glutamate receptor antagonist. Abstr.Soc.Neurosci.
- Lavreysen [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol.Pharmacol. 2003 PMID: 12695537
Product Specific Notices for NPS 2390
For research use only
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