NNC 26-9100

Name: NNC 26-9100
Brand: Tocris Bioscience
SKU: 2440

Tocris Bioscience, part of Bio-Techne | Catalog # 2440

Citations (3)

COA / SDS

Selective sst4 agonist

Key Product Details

Description:	Selective sst₄ agonist
Chemical Name:	1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea
Purity:	≥98% (HPLC)
Molecular Weight:	556.35

View Full Technical Details for NNC 26-9100

Technical Data
Citations

Biological Activity for NNC 26-9100

NNC 26-9100 is a somatostatin sst₄ receptor agonist that displays > 100-fold selectivity over sst₂ receptors (K_i values are 6 and 621 nM for sst₄ and sst₂ receptors respectively). Potently inhibits forskolin-induced cAMP accumulation (EC₅₀ = 26 nM).

Compound Libraries for NNC 26-9100

NNC 26-9100 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NNC 26-9100

M. Wt	556.35
Formula	C₂₂H₂₅N₆Cl₂SBr
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	199522-35-5
PubChem ID	9893924
InChi Key	UREJDUPKGMFJRU-UHFFFAOYSA-N
Smiles	ClC1=C(Cl)C=C(CN(CCCNC(=S)NCCCC2=CNC=N2)C2=CC=C(Br)C=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NNC 26-9100

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.82	50
	ethanol	27.82	50

Preparing Stock Solutions for NNC 26-9100

The following data is based on the product molecular weight 556.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.59 mL	17.97 mL	35.95 mL
2.5 mM	0.72 mL	3.59 mL	7.19 mL
5 mM	0.36 mL	1.80 mL	3.59 mL
25 mM	0.07 mL	0.36 mL	0.72 mL

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References for NNC 26-9100

References are publications that support the biological activity of the product.

Liu 2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity. Curr.Pharm.Des. 1999 PMID: 10101224
Liu Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas. J.Med.Chem. 1998 PMID: 9822540