NGB 2904

Name: NGB 2904
Brand: Tocris Bioscience
SKU: 2635

Tocris Bioscience, part of Bio-Techne | Catalog # 2635

Citations (3)

COA / SDS

Potent and selective D3 antagonist

Key Product Details

Description:	Potent and selective D₃ antagonist
Chemical Name:	N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	530.92

View Full Technical Details for NGB 2904

Technical Data
Citations

Biological Activity for NGB 2904

NGB 2904 is a potent and selective dopamine D₃ receptor antagonist (K_ivalues are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D₃, D₂, 5-HT₂, α₁, D₄, D₁ and D₅ receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC₅₀ = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.

Compound Libraries for NGB 2904

NGB 2904 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NGB 2904

M. Wt	530.92
Formula	C₂₈H₂₉Cl₂N₃O.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	189061-11-8
PubChem ID	19366304
InChi Key	PFIWYJNBKGCVFM-UHFFFAOYSA-N
Smiles	Cl.ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNC(=O)C2=CC=C3C(CC4=CC=CC=C34)=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NGB 2904

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	13.27	25
	ethanol	2.65	5

Preparing Stock Solutions for NGB 2904

The following data is based on the product molecular weight 530.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	7.53 mL	37.67 mL	75.34 mL
1.25 mM	1.51 mL	7.53 mL	15.07 mL
2.5 mM	0.75 mL	3.77 mL	7.53 mL
12.5 mM	0.15 mL	0.75 mL	1.51 mL

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References for NGB 2904

References are publications that support the biological activity of the product.

Xi The novel DA D₃ receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. Neuropsychopharmacology 2006 PMID: 16205781
Pritchard The DA D₃ receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharmacol.Biochem.Behav. 2007 PMID: 17408730
Yuan NGB 2904 and NGB 2849: two highly selective DA D₃ receptor antagonists. Bioorg.Med.Chem.Lett. 1998 PMID: 9873609