(-)-Quinpirole hydrochloride
Tocris Bioscience a Bio-Techne Brand
Key Product Details
Description: | Selective D2-like agonist |
Chemical Name: | (4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 255.79 |
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Citations for (-)-Quinpirole hydrochloride (39)
Citations are publications that use Bio-Techne products. Selected citations for (-)-Quinpirole hydrochloride include:
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Pedersen et al.
(2021)
A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors.
J Biol Chem.
296:100503
PMID: 33684444 -
Dorst et al.
(2020)
Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
Nat Commun.
11:5113
PMID: 33037215 -
Akoume et al.
(2019)
A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
Sci Rep.
9:10074
PMID: 31296888 -
Verharen et al.
(2019)
Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making.
Neurophsychopharmacology.
44:2195
PMID: 31254972 -
Matsui and Alvarez
(2018)
Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
Cell Rep.
23(13):3852
PMID: 29949769 -
Zhang
(2018)
DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs.
Invest Ophthalmol Vis Sci.
59(11):4441
PMID: 30193315 -
Dai et al.
(2018)
Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner.
Exp Mol Med.
50:148
PMID: 30429454 -
Lassus et al.
(2018)
Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
Sci Rep.
8:17461
PMID: 30498197 -
Jain et al.
(2018)
Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.
Am J Physiol Endocrinol Metab.
315:E357
PMID: 29812984 -
Beas et al.
(2018)
The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
Nat Neurosci.
21:963
PMID: 29915192 -
Choi
(2017)
Role of DA D2 receptor in stress-induced myelin loss.
Sci Rep.
7(1):11654
PMID: 28912499 -
Leyrer-Jackson
(2017)
Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex.
Physiol Rep.
5(22):e13499
PMID: 29150590 -
Snyder et al.
(2017)
Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness.
J Biol Chem.
292:7208
PMID: 28275053 -
Leng et al.
(2017)
Activation of DRD5 inhibits tumor growth by autophagic cell death.
Autophagy.
13:1404
PMID: 28613975 -
Borgs et al.
(2016)
DArgic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
Scientific Reports.
6:33377
PMID: 27640816 -
Picton et al.
(2016)
Mechanisms underlying the endogenous DArgic inhibition of spinal locomotor circuit function in Xenopus tadpoles.
Scientific Reports.
6:35749
PMID: 27760989 -
Tozzi et al.
(2015)
Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
Front Cell Neurosci.
9:192
PMID: 26074768 -
Xing et al.
(2015)
DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
Neuropsychopharmacology.
9:310
PMID: 26388722 -
Wang et al.
(2015)
A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation.
Proc Natl Acad Sci U S A.
11:2057
PMID: 26649942 -
Shin et al.
(2015)
Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
Nat Neurosci.
112:8124
PMID: 26080439 -
Spulber et al.
(2014)
PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae.
PLoS One.
9:e94227
PMID: 24740186 -
Ahmadiantehrani and Ron
(2013)
DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
J Neurochem.
2013;
PMID: 23373701 -
Luque-Rojas et al.
(2013)
Hyperactivity induced by the DA D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice.
Int J Neuropsychopharmacol.
16:661
PMID: 22647577 -
Hutchinson et al.
(2012)
Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin.
Eur J Neurosci.
37:321
PMID: 21956448 -
Hook et al.
(2012)
DArgic modulation of ganglion-cell photoreceptors in rat.
Autophagy.
35:507
PMID: 22304466 -
Ferraro et al.
(2012)
A novel mechanism of cocaine to enhance DA d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study.
J Neurosci.
37:1856
PMID: 22453136 -
Gantz et al.
(2011)
Loss of Mecp2 in substantia nigra DA neurons compromises the nigrostriatal pathway.
J Neurosci.
31:12629
PMID: 21880923 -
Yoon et al.
(2011)
Wnt5a-DA D2 receptor interactions regulate DA neuron development via extracellular signal-regulated kinase (ERK) activation.
Neuropsychopharmacology.
286:15641
PMID: 21454669 -
Burgess et al.
(2010)
DArgic regulation of sleep and cataplexy in a murine model of narcolepsy.
Sleep.
33:1295
PMID: 21061851 -
Higley and Sabatini
(2010)
Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
Nat Neurosci.
13:958
PMID: 20601948 -
Deng et al.
(2010)
MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
J Biol Chem.
13:1128
PMID: 20711186 -
Goffin et al.
(2010)
DA-dependent tuning of striatal inhibitory synaptogenesis.
Neuron.
30:2935
PMID: 20181591 -
Napolitano et al.
(2010)
Role of aberrant striatal DA D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine.
J Neurosci.
30:11043
PMID: 20720111 -
Chuhma et al.
(2009)
DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
Neuroscience.
164:1068
PMID: 19729052 -
Kitada et al.
(2007)
Impaired DA release and synaptic plasticity in the striatum of PINK1-deficient mice.
Proc Natl Acad Sci U S A.
104:11441
PMID: 17563363 -
Zapata et al.
(2007)
Regulation of DA transporter function and cell surface expression by D3 DA receptors.
J Biol Chem.
282:35842
PMID: 17923483 -
González-Maeso et al.
(2007)
Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
PLoS One.
53:439
PMID: 17270739 -
Melis et al.
(2004)
Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area DA neurons through activation of CB1 receptors.
J Neurosci.
24:53
PMID: 14715937 -
Marchese et al.
(2003)
Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications.
Br J Pharmacol.
140:520
PMID: 12970091
There are no citations that match your criteria.
Customer Reviews for (-)-Quinpirole hydrochloride (2)
Customer Images
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Species: MouseAssay Type: In Vivoquinpirole(1 μΜ)
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Species: MouseAssay Type: Ex VivoVoltammetry experiments were used to measure evoked dopamine release. Quinpirole (30nM) reduces dopamine release considerably (near IC50 in dorsal striatum), which was reversed by sulpiride (600nM). Drug works every time!Goes into water well. We usually make up a 1 mM stock for many experiments.
There are no reviews that match your criteria.