N-methylated pomalidomide
Tocris Bioscience, part of Bio-Techne | Catalog # 7716
Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control
Key Product Details
Description
Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control
Product Description
N-methylated pomalidomide is a functionalized cereblon ligand for PROTAC® research and development. Can be used to generate negative controls for Pomalidomide (Cat. No. 6302)-based Degraders. Does not bind to cereblon. Part of a range of functionalized tool molecules for PROTAC R&D. Can also be used as a Pomalidomide negative control.Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
287.27
Formula
C14H13N3O4
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
CAS Number
1352827-50-9
PubChem ID
58572149
InChI Key
YSWQOCGODHPKED-UHFFFAOYSA-N
SMILES
O=C1C=2C=CC=C(N)C2C(=O)N1C3C(=O)N(C(=O)CC3)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.73 | 100 |
Preparing Stock Solutions
for N-methylated pomalidomide
The following data is based on the product molecular weight 287.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.48 mL | 17.41 mL | 34.81 mL |
| 5 mM | 0.70 mL | 3.48 mL | 6.96 mL |
| 10 mM | 0.35 mL | 1.74 mL | 3.48 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Product Specific Notices for N-methylated pomalidomide
For research use only
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