N-Acetylcysteine amide

Product Description

N-Acetylcysteine amide is a glutathione (GSH) precursor and cell-permeable antioxidant. N-Acetylcysteine amide replenishes intracellular Glutathione (GSH). N-Acetylcysteine amide directly reduces intracellular Glutathione disulfide (GSSG) to GSH without glutathione peroxidase. N-Acetylcysteine amide has anti-inflammatory activity through regulation of activation of NF-κB and HIF-1α, as well as modulation of reactive oxygen species. N-Acetylcysteine amide improves neuronal mitochondrial bioenergetics, reduces tissue damage and enhances functional recovery following spinal cord injury in rats. N-Acetylcysteine amide also enhances behavioral recovery in rats following traumatic brain injury. Neuroprotective. N-Acetylcysteine amide can be used in a small molecule cocktail to generate 3D culture of lung alveolar cells (see protocol below).

For more information about how N-Acetylcysteine amide may be used, see our protocol: 3D Culture of Lung Alveolar Cells

Solubility

Preparing Stock Solutions for N-Acetylcysteine amide

The following data is based on the product molecular weight 162.21

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.16 mL	30.82 mL	61.65 mL
5 mM	1.23 mL	6.16 mL	12.33 mL
10 mM	0.62 mL	3.08 mL	6.16 mL
50 mM	0.12 mL	0.62 mL	1.23 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Pandya N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Exp.Neurol. 2014 PMID: 24792639
• Tu The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases. Aging Dis 2019 PMID: 31165007
• Patel N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma. Exp.Neurol. 2014 PMID: 24805071