Mycophenolate mofetil
Tocris Bioscience, part of Bio-Techne | Catalog # 4102
Inosine monophosphate dehydrogenase (IMPDH) inhibitor
Key Product Details
Description
Inosine monophosphate dehydrogenase (IMPDH) inhibitor
Product Description
Mycophenolate mofetil is an immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA, a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.Product Specifications
Molecular Weight
433.49
Formula
C23H31NO7
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester
CAS Number
128794-94-5
PubChem ID
5281078
InChI Key
RTGDFNSFWBGLEC-SYZQJQIISA-N
SMILES
O=C(OC2)C1=C2C(C)=C(OC)C(C/C=C(C)/CCC(OCCN3CCOCC3)=O)=C1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.35 | 100 | |
| Ethanol | 4.33 | 10 |
Preparing Stock Solutions
for Mycophenolate mofetil
The following data is based on the product molecular weight 433.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.31 mL | 11.53 mL | 23.07 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.31 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Roos In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophen. mofetil. J.Pharm.Exp.Ther.
- Allison and Eugui Purine metabolism and immunosuppressive effects of mycophen. mofetil (MMF). Clin.Transplant. 1996 PMID: 8680053
Product Specific Notices for Mycophenolate mofetil
For research use only
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