Mycophenolic acid

Name: Mycophenolic acid
Brand: tocris
SKU: 1505

Catalog # 1505

Citations (1)

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Key Product Details

Description:	Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Chemical Name:	6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	320.34

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Biological Activity

Mycophenolic acid is an immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo. Potently inhibits inosine monophosphate dehydrogenase (IMPDH), thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.

Compound Libraries

Mycophenolic acid is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	320.34
Formula	C₁₇H₂₀O₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	24280-93-1
PubChem ID	446541
InChi Key	HPNSFSBZBAHARI-RUDMXATFSA-N
Smiles	COC1=C(C)C2=C(C(=O)OC2)C(O)=C1C\C=C(/C)CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.03	100

Preparing Stock Solutions

The following data is based on the product molecular weight 320.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.61 mL	31.22 mL
5 mM	0.62 mL	3.12 mL	6.24 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References

References are publications that support the biological activity of the product.

Allison Mechanisms of action of mycophenolic acid. Ann.N.Y.Acad.Sci. 1993 PMID: 7906496
Chapman Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br.J.Pharmacol. 1997 PMID: 9422796
Eugui Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depeletion. Scand.J.Immunol. 1991 PMID: 1826793
Goldberg Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 1998 PMID: 9694962
Senda Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Transplantation 1995 PMID: 7482723
Zadina A potent and selective endogenous agonist for the μ-opiate receptor. Nature 1997 PMID: 9087409

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Mycophenolic acid include:

Gomez et al. (2015) Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate. PLoS One. 10:e0133862
PMID: 26288179

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Product Documents

COA

Certificate of Analysis

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Mycophenolic acid

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Technical Data

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References

Citations (1)

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COA

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