Mycophenolic acid
Tocris Bioscience, part of Bio-Techne | Catalog # 1505
Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Key Product Details
Description
Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Product Description
Mycophenolic acid is an immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo. Potently inhibits inosine monophosphate dehydrogenase (IMPDH), thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.Product Specifications
Molecular Weight
320.34
Formula
C17H20O6
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid
CAS Number
24280-93-1
PubChem ID
446541
InChI Key
HPNSFSBZBAHARI-RUDMXATFSA-N
SMILES
COC1=C(C)C2=C(C(=O)OC2)C(O)=C1C\C=C(/C)CCC(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.03 | 100 |
Preparing Stock Solutions
for Mycophenolic acid
The following data is based on the product molecular weight 320.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.61 mL | 31.22 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zadina A potent and selective endogenous agonist for the μ-opiate receptor. Nature 1997 PMID: 9087409
- Senda Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Transplantation 1995 PMID: 7482723
- Goldberg Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 1998 PMID: 9694962
- Eugui Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depeletion. Scand.J.Immunol. 1991 PMID: 1826793
- Chapman Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br.J.Pharmacol. 1997 PMID: 9422796
- Allison Mechanisms of action of mycophenolic acid. Ann.N.Y.Acad.Sci. 1993 PMID: 7906496
Product Specific Notices for Mycophenolic acid
For research use only
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