MU 1742
Tocris Bioscience, part of Bio-Techne | Catalog # 7979
Potent and selective CK1α, CK1δ and CK1ε inhibitor
Key Product Details
Description
Potent and selective CK1α, CK1δ and CK1ε inhibitor
Product Description
MU 1742 is a potent and selective casein kinase 1α (CK1α), CK1δ and CK1ε inhibitor (IC50 values are 6, 7 and 28 nM for CK1δ, CK1α and CK1ε respectively). In vivo, MU 1742 inhibits CK1δ/ε-dependent DVL3 phosphorylation in mouse lung tissue. MU 1742 is orally bioavailable.Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MU 1742 probe summary on the SGC website.Product Specifications
Molecular Weight
408.46
Formula
C22H22F2N6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-(1-((4-Fluoro-1-methylpiperidin-4-yl)methyl)-4-(5-fluoropyridin-2-yl)-1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine
CAS Number
3095089-18-9
PubChem ID
167312208
InChI Key
SWOIFXHMBKFCRM-UHFFFAOYSA-N
SMILES
FC1=CN=C(C=C1)C2=C(C3=CC=NC4=C3C=CN4)N(CC5(F)CCN(C)CC5)C=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.85 | 100 | |
| Ethanol | 40.85 | 100 |
Preparing Stock Solutions
for MU 1742
The following data is based on the product molecular weight 408.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.24 mL | 24.48 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.90 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Němec Discovery of potent and exquisitely selective inhibitors of kinase CK1 with tunable isoform selectivity. Angew.Chem.Int.Ed.Engl. 2023 PMID: 36625768
Product Specific Notices for MU 1742
For research use only
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