MTEP hydrochloride

Name: MTEP hydrochloride
Brand: Tocris Bioscience
SKU: 2921

Catalog # 2921 | Tocris Bioscience a Bio-Techne Brand

Citations (11)

COA / SDS

Potent and selective mGlu5 antagonist

Key Product Details

Description:	Potent and selective mGlu₅ antagonist
Chemical Name:	3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	236.72

View Full Technical Details for MTEP hydrochloride

Technical Data
Citations (11) / Reviews

Biological Activity for MTEP hydrochloride

MTEP hydrochloride is a potent, selective and non-competitive mGlu₅ antagonist (IC₅₀ = 5 nM in Ca²⁺-flux assay; K_i= 16 nM). Displays anxiolytic activity in vivo and is orally active.

Licensing Information

Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)

Compound Libraries for MTEP hydrochloride

MTEP hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MTEP hydrochloride

M. Wt	236.72
Formula	C₁₁H₈N₂S.HCl
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1186195-60-7
PubChem ID	45073467
InChi Key	YCIOJDKGCWAHLR-UHFFFAOYSA-N
Smiles	CC1=NC(C#CC2=CN=CC=C2)=CS1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MTEP hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	23.67	100
	DMSO	23.67	100

Preparing Stock Solutions for MTEP hydrochloride

The following data is based on the product molecular weight 236.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.22 mL	21.12 mL	42.24 mL
5 mM	0.84 mL	4.22 mL	8.45 mL
10 mM	0.42 mL	2.11 mL	4.22 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for MTEP hydrochloride

References are publications that support the biological activity of the product.

Bradbury Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice. J.Pharmacol.Exp.Ther. 2005 PMID: 15590770
Roppe 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity. Bioorg.Med.Chem.Lett. 2004 PMID: 15225713
Klodzinska Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA_A signaling. Neuropharmacology 2004 PMID: 15275823
Cosford 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J.Med.Chem. 2003 PMID: 12519057
Brodkin Reduced stress-induced hyperthermia in mGluR5 knockout mice. Eur.J.Neurosci. 2002 PMID: 12473093

Citations for MTEP hydrochloride (11)

Showing 1 - 10 of 11 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for MTEP hydrochloride include:

Lim et al. (2018) Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures. Int J Mol Sci. 19
PMID: 30274399
Thomson et al. (2017) Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome. Neuron. 95:550
PMID: 28772121
Arsenault et al. (2015) Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS. PLoS One. 10:e0142093
PMID: 26536027
Reissner et al. (2015) Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Elife. 20:316
PMID: 24612076
Rosa et al. (2015) Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. Mol Brain. 4
PMID: 26274565
Guimaraes et al. (2015) The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates. Cell Death Dis. 8:24
PMID: 25885370
Pollard et al. (2014) Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator. J Psychopharmacol. 28:935
PMID: 25031220
Jurgens et al. (2012) Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus. PLoS One. 7:e45717
PMID: 23029198
Ren et al. (2012) Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model. Anesthesiology. 116:122
PMID: 22123524
Sumislawski et al. (2011) Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. Neuropsychopharmacology. 36:2750
PMID: 21849983
Tronson et al. (2010) Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear. Addict Biol. 68:1007
PMID: 21075228

There are no citations that match your criteria.