MPEP hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1212

Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors
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Key Product Details

Description

Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors

View all Group I mGluR Antagonists »

Product Description

MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.

Product Specifications

Molecular Weight

229.71

Formula

C14H11N.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-Methyl-6-(phenylethynyl)pyridine hydrochloride

CAS Number

219911-35-0

PubChem ID

9794588

InChI Key

PKDHDJBNEKXCBI-UHFFFAOYSA-N

SMILES

Cl.CC1=CC=CC(=N1)C#CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.15 5 with gentle warming
DMSO 22.97 100

Preparing Stock Solutions for MPEP hydrochloride

The following data is based on the product molecular weight 229.71

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.35 mL 21.77 mL 43.53 mL
5 mM 0.87 mL 4.35 mL 8.71 mL
10 mM 0.44 mL 2.18 mL 4.35 mL
50 mM 0.09 mL 0.44 mL 0.87 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for MPEP hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MPEP hydrochloride

For research use only

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