MNI caged kainic acid

Name: MNI caged kainic acid
Brand: Tocris Bioscience
SKU: 2225

Tocris Bioscience a Bio-Techne Brand

Catalog # 2225

Citations (1)

COA / SDS

Discontinued Product

2225 has been discontinued. View all Caged Compounds products.

Key Product Details

Description:	Caged kainic acid
Chemical Name:	(2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid 4-methoxy-7-nitro-1H-indolinyl amide
Purity:	≥99% (HPLC)
Molecular Weight:	389.4

View Full Technical Details for MNI caged kainic acid

Biological Activity for MNI caged kainic acid

Kainic acid (Cat.No. 0222) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Generates large inward currents at resting membrane potential upon wide field photolysis in Purkinje neurons. Selectively photoactivates kainate receptors when used in conjunction with an AMPA antagonist, such as GYKI 53655 (Cat.No. 2555). Suitable for uncaging with 300-380 nm excitation. Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation. Also suitable for two-photon uncaging experiments at 720 nm.

Licensing Information

Sold under licence from the Medical Research Council

Technical Data for MNI caged kainic acid

M. Wt	389.4
Formula	C₁₉H₂₃N₃O₆
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1315378-75-6
PubChem ID	57414719
InChi Key	IQGCUMUIYXHZOT-AHIWAGSCSA-N
Smiles	C=[C@@](C)[C@@H]1[C@H](CC(N2C(C([N+]([O-])=O)=CC=C3OC)=C3CC2)=O)[C@@H]([C@](O)=O)NC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MNI caged kainic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	1.95	5 with gentle warming
	DMSO	38.94	100

Preparing Stock Solutions for MNI caged kainic acid

The following data is based on the product molecular weight 389.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.84 mL	25.68 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for MNI caged kainic acid

References are publications that support the biological activity of the product.

Passlick and Ellis-Davies Comparative one- and two-photon uncaging of MNI-glutamate and MNI-kainate on hippocampal CA1 neurons. J.Neurosci.Methods. 2017 PMID: 29051090
Palma-Cerda New caged neurotransmitter analogues based on methoxy-nitroindole and nitrophenylethoxycarbonyl caging groups are selective for glutamate receptor subtypes. Neuropharmacology 2013 PMID: 22609535
Maier Comparative analysis of inhibitor effects of caged ligands for the NMDA receptor. J.Neurosci.Meths. 2005 PMID: 15652611

Citations for MNI caged kainic acid (1)

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Citations are publications that use Bio-Techne products. Selected citations for MNI caged kainic acid include:

Passlick and Ellis-Davies (2017) Comparative one- and two-photon uncaging of MNI-glutamate and MNI-kainate on hippocampal CA1 neurons. J.Neurosci.Methods.. 293:321
PMID: 29051090

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