MM 54

Name: MM 54
Brand: Tocris Bioscience
SKU: 5992

Tocris Bioscience, part of Bio-Techne | Catalog # 5992

Citations (3)

COA / SDS

Potent apelin antagonist

Key Product Details

Description:	Potent apelin antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1737.15

View Full Technical Details for MM 54

Technical Data
Citations

Biological Activity for MM 54

MM 54 is a potent apelin receptor antagonist (K_i = 82 nM; IC₅₀ = 93 nM). Antagonizes the inhibitory affect of [Pyr¹]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.

Technical Data for MM 54

M. Wt	1737.15
Formula	C₇₀H₁₂₁N₂₉O₁₅S₄
Single Letter Sequence	CRPRLCKHCRPRLC (Modifications: Disulfide bridges: 1-6, 9-14)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1313027-43-8
PubChem ID	122705991
InChi Key	BMJYNYGARUVBJU-CSRTWURCSA-N
Smiles	[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MM 54

Solubility

Soluble to 2mg/ml in water

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References for MM 54

References are publications that support the biological activity of the product.

Harford-Wright Pharmacological targeting of apelin impairs glioblastoma growth. Brain 2017 PMID: 29053791
Macaluso Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem 2011 PMID: 21560248