[Pyr¹]-Apelin-13

Name: [Pyr 1 ]-Apelin-13
Brand: Tocris Bioscience
SKU: 2420

Tocris Bioscience, part of Bio-Techne | Catalog # 2420

Citations (7)

COA / SDS

Potent peptide apelin agonist

Key Product Details

Description:	Potent peptide apelin agonist
Alternative Names:	[pGlu¹]-Apelin-13
Purity:	≥95% (HPLC)
Molecular Weight:	1533.81

View Full Technical Details for [Pyr¹]-Apelin-13

Technical Data
Citations

Biological Activity for [Pyr¹]-Apelin-13

[Pyr¹]-Apelin-13 is a highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC₅₀ = 0.37 nM) that displays potent vascular effects in vivo.

Technical Data for [Pyr¹]-Apelin-13

M. Wt	1533.81
Formula	C₆₉H₁₀₈N₂₂O₁₆S
Single Letter Sequence	XRPRLSHKGPMPF (Modifications: X = Glp)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	217082-60-5
PubChem ID	25085173
InChi Key	GGMAXEWLXWJGSF-PEWBXTNBSA-N
Smiles	[H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for [Pyr¹]-Apelin-13

Solubility

Soluble to 1mg/ml in water

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References for [Pyr¹]-Apelin-13

References are publications that support the biological activity of the product.

Kleinz Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 2005 PMID: 15907343
Kagiyama Central and peripheral cardiovascular actions of apelin in conscious rats. Regul.Pept. 2005 PMID: 15582714
Tatemoto Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm.
Katugampola [¹²⁵I]-(Pyr¹)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br.J.Pharmacol. 2001 PMID: 11250876

[Pyr¹]-Apelin-13

Tocris Bioscience, part of Bio-Techne | Catalog # 2420

Key Product Details

Biological Activity for [Pyr¹]-Apelin-13

Technical Data for [Pyr¹]-Apelin-13

Solubility for [Pyr¹]-Apelin-13

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [Pyr¹]-Apelin-13

Product Documents for [Pyr¹]-Apelin-13

COA

Certificate of Analysis

SDS

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[Pyr1]-Apelin-13

Tocris Bioscience, part of Bio-Techne | Catalog # 2420

Key Product Details

Biological Activity for [Pyr1]-Apelin-13

Technical Data for [Pyr1]-Apelin-13

Solubility for [Pyr1]-Apelin-13

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for [Pyr1]-Apelin-13

Product Documents for [Pyr1]-Apelin-13

COA

Certificate of Analysis

SDS

[Pyr¹]-Apelin-13

Biological Activity for [Pyr¹]-Apelin-13

Technical Data for [Pyr¹]-Apelin-13

Solubility for [Pyr¹]-Apelin-13

References for [Pyr¹]-Apelin-13

Product Documents for [Pyr¹]-Apelin-13