ML 382

Name: ML 382
Brand: Tocris Bioscience
SKU: 5738

Tocris Bioscience, part of Bio-Techne | Catalog # 5738

COA / SDS

MRGPRX1 positive allosteric modulator

Key Product Details

Description:	MRGPRX1 positive allosteric modulator
Chemical Name:	2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	360.43

View Full Technical Details for ML 382

Technical Data
Citations

Biological Activity for ML 382

ML 382 is a selective MRGPRX1 positive allosteric modulator (EC₅₀ = 190 nM). Exhibits selectivity for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters. Enhances BAM (8-22) potency at MRGPRX1 by 7-fold.

Technical Data for ML 382

M. Wt	360.43
Formula	C₁₈H₂₀N₂O₄S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1646499-97-9
PubChem ID	71598556
InChi Key	RCSLEKLNDJJJLF-UHFFFAOYSA-N
Smiles	O=C(NC1=C(OCC)C=CC=C1)C2=C(NS(C3CC3)(=O)=O)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 382

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.04	100
	ethanol	7.21	20 with gentle warming

Preparing Stock Solutions for ML 382

The following data is based on the product molecular weight 360.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.87 mL	27.74 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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Reconstitution Calculator

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References for ML 382

References are publications that support the biological activity of the product.

Wen Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 2015 PMID: 25209672