ML 382
Tocris Bioscience, part of Bio-Techne | Catalog # 5738
MRGPRX1 positive allosteric modulator
Key Product Details
Description
MRGPRX1 positive allosteric modulator
Product Description
ML 382 is a selective MRGPRX1 positive allosteric modulator (EC50 = 190 nM). Exhibits selectivity for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters. Enhances BAM (8-22) potency at MRGPRX1 by 7-fold.Product Specifications
Molecular Weight
360.43
Formula
C18H20N2O4S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
CAS Number
1646499-97-9
PubChem ID
71598556
InChI Key
RCSLEKLNDJJJLF-UHFFFAOYSA-N
SMILES
O=C(NC1=C(OCC)C=CC=C1)C2=C(NS(C3CC3)(=O)=O)C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.04 | 100 | |
| Ethanol | 7.21 | 20 with gentle warming |
Preparing Stock Solutions
for ML 382
The following data is based on the product molecular weight 360.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.87 mL | 27.74 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.55 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for ML 382
For research use only
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