BAM (8-22)

Name: BAM (8-22)
Brand: Tocris Bioscience
SKU: 1763
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1763

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Citations (10)

COA / SDS

Potent MRGPRX1 agonist

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Technical Data
Citations & Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent MRGPRX1 agonist

View all Mas-Related G Protein Coupled Receptor Agonists »

Product Description

BAM (8-22) is an endogenous peptide fragment that is a potent agonist for MRGPRX1 (EC₅₀ values are 8 - 150 nM). It was first isolated from bovine adrenal medulla. Unlike BAM 22P (Cat. No. 1650), BAM (8-22) does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors. BAM (8-22) augments scratching behavior in a cholestatic pruritus mice model. BAM (8-22) attenuates bone cancer pain in mice.

Product Specifications

Molecular Weight

1971.22

Formula

C₉₁H₁₂₇N₂₅O₂₃S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

412961-36-5

PubChem ID

16158367

InChI Key

GOEYECACIBFJGZ-NPAGUKBMSA-N

SMILES

[H]N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Sun Activation of spinal MrgC-Gi-NR2B-nNOS signaling pathway by Mas oncogene-related gene C receptor agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice. Am.J.Transl.Res. 2016 PMID: 27158400
Sanjel BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sci.Rep. 2019 PMID: 31350433
Solinski Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev 2014 PMID: 24867890
Simonin and Kieffer Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 2002 PMID: 11865303
Lembo Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 2002 PMID: 11850634
Chen and Ikeda Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons. J.Neurosci. 2004 PMID: 15163697