Potent endogenous agonist peptide for Mas-related G proteins-coupled receptor X1 (MRGPRX1); isolated from bovine adrenal medulla (EC₅₀ values are 16 - 800 nM) Also potent opioid agonist (IC₅₀ = 1.3 nM in guinea pig ileum preparation). Produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.

Product Specifications

Molecular Weight

2839.24

Formula

C₁₃₀H₁₈₄N₃₈O₃₁S₂

Storage

Desiccate at -20°C

CAS Number

76622-26-9

PubChem ID

16132339

InChI Key

QYDAFJUKVGVEKO-PKOVDKIBSA-N

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Solinski Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 2014 PMID: 24867890
Simonin and Kieffer Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 2002 PMID: 11865303
Lembo Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 2002 PMID: 11850634
Mizuno A new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem.Biophys.Res.Commun. 1980 PMID: 7213356
Hong Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor. Br.J.Pharmacol. 2004 PMID: 14718254

BAM 22P

Tocris Bioscience, part of Bio-Techne | Catalog # 1650

Key Product Details

Description

Alternative Names

View all Miscellaneous/Non-selective Opioid Agonists »

Product Description