MK 0677

Name: MK 0677
Brand: Tocris Bioscience
SKU: 5272

Tocris Bioscience, part of Bio-Techne | Catalog # 5272

Citations (15)

COA / SDS

High affinity ghrelin receptor agonist

Key Product Details

Description:	High affinity ghrelin receptor agonist
Alternative Names:	Ibutamoren mesylate,L-163,191
Chemical Name:	2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	624.77

View Full Technical Details for MK 0677

Technical Data
Citations

Biological Activity for MK 0677

MK 0677 is a high affinity ghrelin receptor agonist (pK_i = 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC₅₀ = 1.3 nM) and enhances GH plasma levels in vivo. Also attenuates isoproterenol-induced lipolysis in rat adipocytes in vitro. Orally bioavailable.

Compound Libraries for MK 0677

MK 0677 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MK 0677

M. Wt	624.77
Formula	C₂₇H₃₆N₄O₅S.CH₃SO₃H
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	159752-10-0
PubChem ID	6450830
InChi Key	DUGMCDWNXXFHDE-VZYDHVRKSA-N
Smiles	O=S(N2C1=CC=CC=C1C3(CCN(C([C@H](NC(C(C)(N)C)=O)COCC4=CC=CC=C4)=O)CC3)C2)(C)=O.CS(O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MK 0677

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	31.24	50
	DMSO	62.48	100

Preparing Stock Solutions for MK 0677

The following data is based on the product molecular weight 624.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.60 mL	8.00 mL	16.01 mL
5 mM	0.32 mL	1.60 mL	3.20 mL
10 mM	0.16 mL	0.80 mL	1.60 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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References for MK 0677

References are publications that support the biological activity of the product.

Patchett Design and biological activities of L-163,191 (MK-0677): a potent, orally active GH secretagogue. Proc.Natl.Acad.Sci.U.S.A. 1995 PMID: 7624358
Mucciolo Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a GH secretagogue receptor. Eur.J.Pharmacol. 2004 PMID: 15363972
Bennett GH secretagogues and GH releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor. Mol.Pharmacol. 2009 PMID: 19625579