Mirin

Name: Mirin
Brand: Tocris Bioscience
SKU: 3190

Tocris Bioscience a Bio-Techne Brand

Catalog # 3190

Citations (5)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	MRN-ATM pathway inhibitor
Chemical Name:	Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
Purity:	≥99% (HPLC)
Molecular Weight:	220.25

View Full Technical Details for Mirin

Biological Activity for Mirin

Mirin is a Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC₅₀ = 12 μM) and induces G₂ cell cycle arrest. Also blocks homology-directed repair in vitro.

Compound Libraries for Mirin

Mirin is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Mirin

M. Wt	220.25
Formula	C₁₀H₈N₂O₂S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1198097-97-0
PubChem ID	1206243
InChi Key	YBHQCJILTOVLHD-YVMONPNESA-N
Smiles	OC(C=C1)=CC=C1/C=C2/C(NC(S2)=N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mirin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.02	100

Preparing Stock Solutions for Mirin

The following data is based on the product molecular weight 220.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.54 mL	22.70 mL	45.40 mL
5 mM	0.91 mL	4.54 mL	9.08 mL
10 mM	0.45 mL	2.27 mL	4.54 mL
50 mM	0.09 mL	0.45 mL	0.91 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Mirin

References are publications that support the biological activity of the product.

Garner Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 2009 PMID: 19219009
Dupre A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 2008 PMID: 18176557
Stivers Small molecule versus DNA repair mechanisms. Nat.Chem.Biol. 2008 PMID: 18202674

Citations for Mirin (5)

Showing 1 - 5 of 5 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Mirin include:

Hollingworth et al. (2017) Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 91
PMID: 28855246
Hampp et al. (2016) DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression Proc Natl Acad Sci U S A.. 113:E4311
PMID: 27407148
Berte et al. (2016) Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs. Mol Cancer Ther. 15:2665
PMID: 27474153
Bothmer et al. (2013) Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. Regul Pept. 210:115
PMID: 23254285
Lee and Dunphy (2013) The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Mol Biol Cell. 24:1343
PMID: 23468519

There are no citations that match your criteria.